5-HT4 Receptors
Serotonin 5-HT4 receptors are located primarily in nigrostriatal and mesolimbic systems and smooth muscle. The receptor plays a role in memory and learning, anxiety, visual perception and smooth muscle relaxation.
5-HT4 Receptor Agonists |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 4374 | BIMU 8 |
| Potent 5-HT4 agonist | |
| 1695 | Cisapride |
| 5-HT4 agonist; stimulates intestinal ACh release | |
| 1795 | Zacopride hydrochloride |
| 5-HT4 agonist; also highly potent 5-HT3 antagonist | |
5-HT4 Receptor Antagonists |
|
| Cat. No. | Product Name / Activity |
| 1322 | GR 113808 |
| Potent and selective 5-HT4 antagonist | |
| 1658 | GR 125487 sulfamate |
| Potent and selective 5-HT4 antagonist; active in vivo | |
| 0728 | RS 23597-190 hydrochloride |
| 5-HT4 antagonist | |
| 0991 | RS 39604 hydrochloride |
| 5-HT4 antagonist | |
Serotonin 5-HT4 receptors are located primarily in nigrostriatal and mesolimbic systems and smooth muscle. The receptor plays a role in memory and learning, anxiety, visual perception and smooth muscle relaxation. The human 5-HT4 receptor gene has been localized to chromosome 5 (5q31-33).
External sources of pharmacological information for 5-HT4 Receptors :
Literature for 5-HT4 Receptors
Tocris offers the following scientific literature for 5-HT4 Receptors to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Our 5-HT review summarizes the serotonin receptor subtypes and highlights their importance in mediating various physiological & pharmacological processes.
Request copyRequest PDFWritten by P. Skolnich et al
Our Depression poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder.
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