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Submit ReviewCJ 033466
Description: Selective 5-HT4 partial agonist
Chemical Name: 5-Amino-6-chloro-2-methyl-N-[[1-(2-methylpropyl)-4-piperidinyl]methyl]-imidazo[1,2-a]pyridine-8-carboxamide
Purity: ≥98% (HPLC)
Biological Activity for CJ 033466
CJ 033466 is a potent and selective 5-HT4 partial agonist (EC50= 0.927 nM). Displays > 1000-fold selectivity for 5-HT4 over other 5-HT and D2 receptors. Exhibits gastroprokinetic effects in vivo following oral administration. Weakly blocks hERG (IC50 = 2.6 μM).
Technical Data for CJ 033466
| M. Wt | 377.91 |
| Formula | C19H28ClN5O |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 519148-48-2 |
| PubChem ID | 10429706 |
| InChI Key | ISKHMDNIWXPUGR-UHFFFAOYSA-N |
| Smiles | ClC2=C(N)N1C(C(C(NCC3CCN(CC(C)C)CC3)=O)=C2)=NC(C)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for CJ 033466
References for CJ 033466
References are publications that support the biological activity of the product.
Toga et al (2007) The 5-HT4 agonists cisapride, mosapride, and CJ-033466, a novel potent compound, exhibit different human ether-a-go-go-related gene (hERG)-blocking activities. J.Pharmacol.Sci. 105 207 PMID: 17928736
Mikami et al (2008) 5-Amino-6-chloro-N-[(1-isobutylpiperidin-4-yl)methyl]-2-methylimidazo[1,2-α]pyridine-8-carboxamide (CJ-033,466), a novel and selective 5-hydroxytryptamine4 receptor partial agonist: pharmacological profile in vitro and gastroproki J.Pharmacol.Exp.Ther. 325 190 PMID: 18198343
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Keywords: CJ 033466, CJ 033466 supplier, Selective, 5-HT4, partial, agonists, Serotonin, Receptors, 5-Hydroxytryptamine, CJ033466, 3089, Tocris Bioscience
Citations for CJ 033466
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Currently there are no citations for CJ 033466.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.