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Submit ReviewCLP 290
Description: K+/Cl- cotransporter 2 (KCC2) activator; orally bioavailable prodrug of CLP 257 (Cat. No.5242)
Chemical Name: (Z)-5-Fluoro-2-((4-oxo-2-(tetrahydropyridazin-1(2H)-yl)thiazol-5(4H)-ylidene)methyl)phenyl pyrrolidine-1-carboxylate
Purity: ≥98% (HPLC)
Biological Activity for CLP 290
CLP 290 is a K+/Cl- Cotransporter 2 (KCC2) activator. Activates spinal inhibitory interneurons, restores physiological neuronal activity in the spinal cord and induces functional recovery in a mouse model of spinal cord injury. Also decreases blood vasopressin and glucose levels in mice with Streptozotocin (Cat. No. 1621) induced diabetes mellitus. Orally bioavailable prodrug of CLP 257 (Cat. No.5242).
Compound Libraries for CLP 290
CLP 290 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for CLP 290
| M. Wt | 404.46 |
| Formula | C19H21FN4O3S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1181083-81-7 |
| PubChem ID | 68637267 |
| InChI Key | DIXMMXNNKLCLOM-WJDWOHSUSA-N |
| Smiles | FC1=CC(OC(N2CCCC2)=O)=C(C=C1)/C=C3SC(N4CCCCN4)=NC\3=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CLP 290
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.22 | 50 | |
| ethanol | 2.02 | 5 |
Preparing Stock Solutions for CLP 290
The following data is based on the product molecular weight 404.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.94 mL | 24.72 mL | 49.45 mL |
| 2.5 mM | 0.99 mL | 4.94 mL | 9.89 mL |
| 5 mM | 0.49 mL | 2.47 mL | 4.94 mL |
| 25 mM | 0.1 mL | 0.49 mL | 0.99 mL |
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Product Datasheets for CLP 290
References for CLP 290
References are publications that support the biological activity of the product.
Gagnon et al (2013) Chloride extrusion enhancers as novel therapeutics for neurological diseases. Nat.Med. 19 1524 PMID: 24097188
Kim et al (2019) Long-term ionic plasticity of GABAergic signalling in the hypothalamus. J.Neuroendocrinol. 31 e12753 PMID: 31166034
Chen et al (2018) Reactivation of dormant relay pathways in injured spinal cord by KCC2 manipulations. Cell 174 521 PMID: 30033363
If you know of a relevant reference for CLP 290, please let us know.
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Keywords: CLP 290, CLP 290 supplier, CLP290, CLP257, Selective, KCC2, K+/Cl-, cotransporters, activators, activates, neuropathic, pain, orally, bioavailable, Cotransporter, 2, 6758, Tocris Bioscience
Citations for CLP 290
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.