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CM 11

Cat. No. 6416 Submit a Review Datasheet / COA / SDS
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Description: Homo-PROTAC® for self-degradation of pVHL30
Chemical Name: N1,N20-bis((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,6,9,12,15,18-hexaoxaicosanediamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for CM 11

CM 11 is a PROTAC® for self-degradation of the long form of VHL, pVHL30 (DC50 < 100 nM). Composed of two VHL ligands joined by a linker. Exhibits > 1000-fold increased cellular activity compared to the parent VHL ligand, VH 032. Dimerizes pVHL30 with high avidity in vitro. Induced potent and rapid self-degradation of VHL in cell lines in a highly isoform dependent fashion. Negative control CMP 98 (Cat. No. 6417) also available.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under licence from the University of Dundee

Technical Data for CM 11

E3 ligase VHL
DC50 10-100 nM - Degradation of pVHL30 in HeLa cells after 24 h treatment
Selectivity confirmed by global proteomics No
M. Wt 1179.46
Formula C58H82N8O14S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2244684-49-7
PubChem ID 134160242
InChI Key WGJCHHJGGFCCRS-DEYDLUNASA-N
Smiles CC1=C(C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@H](C(C)(C)C)NC(COCCOCCOCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)=O)=O)C=C2)SC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CM 11

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 117.95 100

Preparing Stock Solutions for CM 11

The following data is based on the product molecular weight 1179.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.85 mL 4.24 mL 8.48 mL
5 mM 0.17 mL 0.85 mL 1.7 mL
10 mM 0.08 mL 0.42 mL 0.85 mL
50 mM 0.02 mL 0.08 mL 0.17 mL

Molarity Calculator

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Product Datasheets for CM 11

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for CM 11

References are publications that support the biological activity of the product.

Maniaci et al (2017) Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat.Commun. 8 830 PMID: 29018234

If you know of a relevant reference for CM 11, please let us know.

View Related Products by Target

Keywords: CM 11, CM 11 supplier, CM11, PROTACs, Proteolysis, targeted, chimeras, E3, ubiquitin, ligase, VHL, PROTAC, active, degraders, degrades, protein, degradation, tpd, Ubiquitin, Ligases, Ligase, Degraders, 6416, Tocris Bioscience

Citations for CM 11

Citations are publications that use Tocris products.

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Literature in this Area

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia