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Submit ReviewCo 102862
Discontinued Product
2642 has been discontinued.
View all Voltage-gated Sodium (Na<sub>V</sub>) Channels products.
Description: State-dependent of voltage-gated sodium channels
Alternative Names: V102862
Chemical Name: 2-[[4-(4-Fluorophenoxy)phenyl]methylene]hydrazinecarboxamide
Purity: ≥99% (HPLC)
Biological Activity for Co 102862
Co 102862 is a broad spectrum, state-dependent blocker of voltage-gated sodium channels. Displays ~ 80-fold higher affinity for inactivated Na+ channels compared to channels in the resting state. Anticonvulsant; displays activity in rodent models of tonic/clonic and partial-complex seizures.
Technical Data for Co 102862
| M. Wt | 273.26 |
| Formula | C14H12FN3O2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 181144-66-1 |
| PubChem ID | 9816959 |
| InChI Key | MHUUDVZSPFRUSK-RQZCQDPDSA-N |
| Smiles | NC(=O)N\N=C\C1=CC=C(OC2=CC=C(F)C=C2)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Co 102862
References for Co 102862
References are publications that support the biological activity of the product.
Ilyin et al (2005) V102862 (Co 102862): a potent, broad-spectrum state-dependent blocker of mammalian voltage-gated sodium channels. Br.J.Pharmacol. 144 801 PMID: 15778702
Ilyin et al (2006) Pharmacology of 2-[4-(4-chloro-2-fluorophenoxy)phenyl]-pyrimidine-4-carboxamide: a potent, broad-spectrum state-dependent sodium channel blocker for treating pain states. J.Pharmacol.Exp.Ther. 318 1083 PMID: 16728593
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Keywords: Co 102862, Co 102862 supplier, State-dependent, Na+, channel, blockers, anticonvulsant, Sodium, NaV, Channels, voltage-gated, voltage-dependent, Co102862, V102862, Voltage-gated, 2642, Tocris Bioscience
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