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Submit ReviewCorticosterone
Description: Endogenous glucocorticoid
Chemical Name: (11β)-11,21-Dihydroxypregn-4-ene-3,20-dione
Purity: ≥99% (HPLC)
Biological Activity for Corticosterone
Corticosterone is an endogenous glucocorticoid that acts as an agonist at glucocorticoid and mineralocorticoid receptors.
Compound Libraries for Corticosterone
Corticosterone is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for Corticosterone
| M. Wt | 346.46 |
| Formula | C21H30O4 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 50-22-6 |
| PubChem ID | 5753 |
| InChI Key | OMFXVFTZEKFJBZ-HJTSIMOOSA-N |
| Smiles | [H][C@@]23CCC1=CC(CC[C@@](C)1[C@]([H])2[C@@H](O)C[C@@]4(C)[C@]([H])3CC[C@@H]4[C@@](CO)=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Corticosterone
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.65 | 100 |
Preparing Stock Solutions for Corticosterone
The following data is based on the product molecular weight 346.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.89 mL | 14.43 mL | 28.86 mL |
| 5 mM | 0.58 mL | 2.89 mL | 5.77 mL |
| 10 mM | 0.29 mL | 1.44 mL | 2.89 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
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Product Datasheets for Corticosterone
References for Corticosterone
References are publications that support the biological activity of the product.
Lu et al (2006) International union of pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors. Pharmacol.Rev. 58 782 PMID: 17132855
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Keywords: Corticosterone, Corticosterone supplier, endogenous, glucocorticoid, receptors, mineralocorticoid, nuclear, steroid, hormone, Glucocorticoid, Receptor, Mineralocorticoid, 3685, Tocris Bioscience
4 Citations for Corticosterone
Citations are publications that use Tocris products. Selected citations for Corticosterone include:
Ahmad et al (2019) Perivascular Adipocytes Store Norepinephrine by Vesicular Transport. Arterioscler Thromb Vasc Biol 39 188 PMID: 30567483
Gang et al (2021) Bag-1 mediates glucocorticoid receptor trafficking to mitochondria after corticosterone stimulation: Potential role in regulating affective resilience. J Neurochem 158 358-372 PMID: 33025573
Roshanak et al (2019) Golgi localized β1-adrenergic receptors stimulate Golgi PI4P hydrolysis by PLCε to regulate cardiac hypertrophy. Elife 8 PMID: 31433293
Shikatani et al (2012) Inhibition of proliferation, migration and proteolysis contribute to corticosterone-mediated inhibition of angiogenesis. PLoS One 7 e46625 PMID: 23056375
Do you know of a great paper that uses Corticosterone from Tocris? Please let us know.
Reviews for Corticosterone
Average Rating: 5 (Based on 1 Review.)
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works well.
By
Anonymous on 03/29/2020
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: rat adrenal medulla chromaffin cells
1 mM
Literature in this Area
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.