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Submit ReviewCortistatin 14
Description: Endogenous neuropeptide; binds sst1 - sst5, ghrelin receptor and MRGPRX2
Purity: ≥95% (HPLC)
Biological Activity for Cortistatin 14
Cortistatin 14 is an endogenous neuropeptide, mainly expressed in the cortex and hippocampus, that has structural and functional similarities to somatostatin-14. Cortistatin 14 displays potency at all somatostatin receptors (sst1 - sst5) and prevents somatostatin-14 binding (IC50 values are 0.09, 0.2, 0.3, 0.3 and 5 nM at sst2, sst4, sst3, sst5 and sst1 receptors, respectively). Also a potent MRGPRX2 agonist (EC50 = 25 nM in HEK293 cells) and binds to the growth hormone secretagog receptor (GHS-R1a). Exhibits neuronal depressant and sleep-modulating properties in vivo.
Technical Data for Cortistatin 14
| M. Wt | 1721.03 |
| Formula | C81H113N19O19S2 |
| Sequence |
PCKNFFWKTFSSCK (Modifications: Disulfide bridge: 2-13) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 193829-96-8 |
| PubChem ID | 16133803 |
| InChI Key | DDRPLNQJNRBRNY-WYYADCIBSA-N |
| Smiles | [H]N1CCC[C@H]1C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Cortistatin 14
| Solubility | Soluble to 0.70 mg/ml in water |
Product Datasheets for Cortistatin 14
References for Cortistatin 14
References are publications that support the biological activity of the product.
Deghenghi et al (2001) Cortistatin, but not somatostatin, binds to GH secretagogue (GHS) receptors of the human pituitary gland. J.Endocrinol.Invest. 24 RC1 PMID: 11227737
Fukusumi et al (1997) Identification and characterization of a novel human cortisan-like peptide. Biochem.Biophys.Res.Comm. 232 157 PMID: 9125122
Spier and de Lecea (2000) Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions. Brain Res. 33 228 PMID: 11011067
Solinski et al (2014) Pharmacology and signaling of MAS-related G protein-coupled receptors. Pharmacol.Rev. 66 570 PMID: 24867890
Robas et al (2003) MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion. J.Biol.Chem. 278 44400 PMID: 12915402
If you know of a relevant reference for Cortistatin 14, please let us know.
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Keywords: Cortistatin 14, Cortistatin 14 supplier, Endogenous, neuropeptide, binds, sst1, sst2, sst3, sst4, sst5, GHS-R1a, Receptors, Somatostatin, Growth, Hormone, Secretagogue, 1a, Ghrelin, Cortistatin14, neuropeptides, mas-related, g, protein-coupled, receptors, MRGPRX2, Mas-related, G, Protein-Coupled, 3374, Tocris Bioscience
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