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Submit ReviewCostunolide
Description: Inhibitor of human telomerase activity
Chemical Name: (3aS,6E,10E,11aR)-3a,4,5,8,9,11a-Hexahydro-6,10-dimethyl-3-methylene-cyclodeca[b]furan-2(3H)-one
Purity: ≥97% (HPLC)
Biological Activity for Costunolide
Costunolide is an inhibitor of human telomerase activity (IC50 = 65 μM in MCF-7 breast cancer cells). Suppresses proliferation and induces apoptosis in a variety of human tumor cell lines. Selectively blocks endothelial cell proliferation induced by VEGF. Inhibits expression of iNOS and IL-1β and disrupts NF-κB activation. Displays anti-inflammatory, antifungal and antiviral properties.
Technical Data for Costunolide
| M. Wt | 232.32 |
| Formula | C15H20O2 |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 553-21-9 |
| PubChem ID | 5281437 |
| InChI Key | HRYLQFBHBWLLLL-AHNJNIBGSA-N |
| Smiles | C/C1=C\[C@@H](OC([C@]2=C)=O)[C@H]2CC/C(C)=C/CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Costunolide
References for Costunolide
References are publications that support the biological activity of the product.
Park et al (1996) Syringin 4-O-β-glucoside, a new phenylpropanoid glycoside, and costunolide, a nitric oxide synthase inhibitor, from the stem bark of Magnolia sieboldi. J.Nat.Prod. 59 1128 PMID: 8988596
Jeong et al (2002) Costunolide, a sesquiterpene lactone from Saussurea lappa, inhibits the VEGFR KDR/Flk-1 signaling pathway. Cancer Lett. 187 129 PMID: 12359360
Choi et al (2005) Inhibitory effects of costunolide on the telomerase activity in human breast carcinoma cells. Cancer Lett. 227 153 PMID: 16112418
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Keywords: Costunolide, Costunolide supplier, inhibitors, inhibits, human, telomerase, activity, Polymerases, Protein, Synthesis, RNA, DNA, Telomerase, DNA,, and, Non-selective, Antivirals, 2483, Tocris Bioscience
5 Citations for Costunolide
Citations are publications that use Tocris products. Selected citations for Costunolide include:
Ramirez et al (2013) Biosynthesis of sesquiterpene lactones in pyrethrum (Tanacetum cinerariifolium). PLoS One 8 e65030 PMID: 23741445
Ahmad et al (2016) Nrf2-driven TERT regulates pentose phosphate pathway in glioblastoma. Cell Death Dis 7 e2213 PMID: 27148686
Liu et al (2018) Kauniolide synthase is a P450 with unusual hydroxylation and cyclization-elimination activity. Nat Commun 9 4657 PMID: 30405138
Liu et al (2011) Reconstitution of the costunolide biosynthetic pathway in yeast and Nicotiana benthamiana. Neuron 6 e23255 PMID: 21858047
Ahmad et al (2017) Telomerase reverse transcriptase (TERT) - enhancer of zeste homolog 2 (EZH2) network regulates lipid metabolism and DNA damage responses in glioblastoma. J Neurochem 143 671 PMID: 28833137
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