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Submit ReviewCP 135807
Description: Selective 5-HT1D agonist
Chemical Name: 3-[[(2R)-1-Methyl-2-pyrrolidinyl]methyl]-N-(3-nitro-2-pyridinyl)-1H-indol-5-amine
Purity: ≥98% (HPLC)
Biological Activity for CP 135807
Selective 5-HT1D receptor agonist. Produces dose-dependent decreases in extracellular 5-HT concentration.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data for CP 135807
| M. Wt | 351.4 |
| Formula | C19H21N5O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 151272-90-1 |
| PubChem ID | 5487088 |
| InChI Key | YPFIYPNOWVPAPR-OAHLLOKOSA-N |
| Smiles | CN(CCC4)[C@H]4CC1=CNC2=C1C=C(NC3=NC=CC=C3[N+]([O-])=O)C=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for CP 135807
References for CP 135807
References are publications that support the biological activity of the product.
Hertel et al (1999) The antipsychotic drug risper. interacts with auto- and hetero-receptors regulating serotonin output in the rat frontal cortex. Neuropharmacology 38 1175 PMID: 10462130
Mansbach et al (1996) CP-135,807, a selective 5-HT1D agonist: effects in drug discrimination and punishment procedures in the pigeon. Psychopharmacology 128 313 PMID: 8972551
Rollema et al (1996) Combined administration of a 5-hydroxytryptamine (5-HT)1D antagonist and a 5-HT reuptake inhibitor synergistically increases 5-HT release in guinea pig hypothalamus in vivo. J.Neurochem. 67 2204 PMID: 8863532
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Keywords: CP 135807, CP 135807 supplier, selective, 5-HT, serotonin, 5-HT1D, receptors, agonists, Pfizer, CP135807, Receptors, 3783, Tocris Bioscience
Citations for CP 135807
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Currently there are no citations for CP 135807.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.