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CP 316819

Cat. No. 3542 2 Citations Submit a Review Datasheet / COA / SDS
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Description: Selective glycogen phosphorylase inhibitor
Chemical Name: 5-Chloro-N-[(1S,2R)-2-hydroxy-3-(methoxymethylamino)-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for CP 316819

CP 316819 is a selective glycogen phosphorylase inhibitor [IC50 values are 0.017 and 0.034 μM against human skeletal muscle glycogen phosphorylase a (huSMGPa) and liver glycogen phosphorylase a (huLGPa) respectively]. Antihyperglycemic agent.

Compound Libraries for CP 316819

CP 316819 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CP 316819

M. Wt 415.87
Formula C21H22ClN3O4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 186392-43-8
PubChem ID 10273347
InChI Key WEQLRDLTRCEUHG-PKOBYXMFSA-N
Smiles O=C(N[C@@H](CC3=CC=CC=C3)[C@H](C(N(OC)C)=O)O)C2=CC1=CC(Cl)=CC=C1N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CP 316819

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.59 100
ethanol 41.59 100

Preparing Stock Solutions for CP 316819

The following data is based on the product molecular weight 415.87. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.4 mL 12.02 mL 24.05 mL
5 mM 0.48 mL 2.4 mL 4.81 mL
10 mM 0.24 mL 1.2 mL 2.4 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets for CP 316819

Certificate of Analysis / Product Datasheet
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Safety Datasheet

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Keywords: CP 316819, CP 316819 supplier, glycogen, phosphorylase, inhibitors, inhibits, antihyperglycemic, antihyperglycaemic, transferases, carbohydrate, metabolism, CP316819, Phosphorylases, 3542, Tocris Bioscience

2 Citations for CP 316819

Citations are publications that use Tocris products. Selected citations for CP 316819 include:

Galow et al (2014) Energy substrates that fuel fast neuronal network oscillations. J Exp Bot 8 398 PMID: 25538552

Jun et al (2021) Glycogen metabolism is dispensable for tumour progression in clear cell renal cell carcinoma. Nat Metab 3 327-336 PMID: 33758423

Do you know of a great paper that uses CP 316819 from Tocris? Please let us know.

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