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CP 339818 hydrochloride

Cat. No. 1399 1 Citation 1 Review Submit a Review Datasheet / COA / SDS

Discontinued Product

1399 has been discontinued.

View all Voltage-gated Potassium (K<sub>V</sub>) Channels products.
Description: Non-peptide, potent KV1.3 channel blocker
Chemical Name: N-[1-(Phenylmethyl)-4(1H)-quinolinylidene]-1 pentanamine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews (1)
Biological Activity Technical Data Datasheets References

Biological Activity for CP 339818 hydrochloride

CP 339818 hydrochloride is a potent, non-peptide KV1.3 channel antagonist that preferentially binds to the C-type inactivated state of the channel (IC50 ~ 200 nM). Inhibits KV1.4 with an IC50 of ~ 300 nM. Selective over KV1.1, KV1.2, KV1.5, KV1.6, KV3.1-4, and KV4.2.

Technical Data for CP 339818 hydrochloride

M. Wt 340.89
Formula C21H24N2.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 478341-55-8
PubChem ID 20761468
InChI Key JIRISCAPZWLWCG-UHFFFAOYSA-N
Smiles CCCCC\N=C2C1=CC=CC=C1N(CC3=CC=CC=C3)C=C/2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for CP 339818 hydrochloride

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for CP 339818 hydrochloride

References are publications that support the biological activity of the product.

Jager et al (1998) Regulation of mammalian Shaker-related K+ channels: evidence for non-conducting closed and non-conducting inactivated. J.Physiol. 506 291 PMID: 9490854

Nguyen et al (1996) Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation. Mol.Pharmacol. 50 1672 PMID: 8967992

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Keywords: CP 339818 hydrochloride, CP 339818 hydrochloride supplier, Non-peptide, potent, KV13, channels, blockers, Potassium, KV, voltage-gated, voltage-dependent, K+, CP339818, hydrochloride, Voltage-Gated, Channels, 1399, Tocris Bioscience

1 Citation for CP 339818 hydrochloride

Citations are publications that use Tocris products. Selected citations for CP 339818 hydrochloride include:

Meredith et al (2015) Kv1 channels and neural processing in vestibular calyx afferents. J Neurosci 9 85 PMID: 26082693

Reviews for CP 339818 hydrochloride

Average Rating: 5 (Based on 1 Review.)

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CP 339818 hydrochloride was used to understand the blocking action on Kv7.1.
By Anonymous on 01/23/2019
Assay Type: In Vitro
Species: Human

The product was used to understand the blocking action on Kv7.1 on increasing concentrations.Its action on repolarization was being assessed.

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