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Submit ReviewCP 424174
Description: Inhibitor of IL-1β post-translational processing; indirectly inhibits NLRP3
Chemical Name: N-[[[4-Chloro-2,6-bis(1-methylethyl)phenyl]amino]carbonyl]-3-(1-hydroxy-1-methylethyl)benzenesulfonamide
Purity: ≥98% (HPLC)
Biological Activity for CP 424174
CP 424174 is an inhibitor of IL-1β post-translational processing (IC50 = 210 nM). Inhibits the formation of mature IL-1β. Indirectly inhibits NLRP3. Active in vivo and orally bioavailable.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data for CP 424174
| M. Wt | 452.99 |
| Formula | C22H29ClN2O4S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 210825-31-3 |
| PubChem ID | 9911728 |
| InChI Key | YRSBLSHMKVQWHP-UHFFFAOYSA-N |
| Smiles | O=S(C1=CC(C(O)(C)C)=CC=C1)(NC(NC2=C(C(C)C)C=C(Cl)C=C2C(C)C)=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for CP 424174
References for CP 424174
References are publications that support the biological activity of the product.
Perregaux et al (2001) Identification and characterization of a novel class of interleukin-1 post-translational processing inhibitors. J.Pharmacol.Exp.Ther. 299 187 PMID: 11561079
Baldwin et al (2016) Inhibiting the inflammasome: a chemical perspective. J.Med.Chem. 59 1691 PMID: 26422006
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Keywords: CP 424174, CP 424174 supplier, CP424174, Inhibitor, IL-1, beta, post-translational, processing, β, NLRP3, inflammasomes, in, vivo, orally, bioavailable, Cytokines, Inflammasomes, 6107, Tocris Bioscience
Citations for CP 424174
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Currently there are no citations for CP 424174.
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