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Submit ReviewCP 945598 hydrochloride
Description: CB1 antagonist
Chemical Name: 1-[8-(2-Chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-(ethylamino)piperidine-4-carboxamide hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for CP 945598 hydrochloride
CP 945598 hydrochloride is a selective, high affinity CB1 antagonist (Ki values are 0.7 and 0.12 nM in binding and functional assays respectively). Displays low affinity for CB2 receptors (Ki = 7600 nM).
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data for CP 945598 hydrochloride
| M. Wt | 546.88 |
| Formula | C25H25Cl2N7O.HCl |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 686347-12-6 |
| PubChem ID | 16223963 |
| InChI Key | KPYUQCJBZGQHPL-UHFFFAOYSA-N |
| Smiles | CCNC(CC4)(C(N)=O)CCN4C1=NC=NC2=C1N=C(C5=C(Cl)C=CC=C5)N2C3=CC=C(Cl)C=C3.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CP 945598 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 10.94 | 20 |
Preparing Stock Solutions for CP 945598 hydrochloride
The following data is based on the product molecular weight 546.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 9.14 mL | 45.71 mL | 91.43 mL |
| 1 mM | 1.83 mL | 9.14 mL | 18.29 mL |
| 2 mM | 0.91 mL | 4.57 mL | 9.14 mL |
| 10 mM | 0.18 mL | 0.91 mL | 1.83 mL |
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Product Datasheets for CP 945598 hydrochloride
References for CP 945598 hydrochloride
References are publications that support the biological activity of the product.
Griffith et al (2009) Discovery of 1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxylic acid amide hydrochloride (CP-945,598), a novel, potent, and selective cannabinoid type 1 receptor antagonist. J.Med.Chem. 52 234 PMID: 19102698
Hadcock et al (2010) In vitro and in vivo pharmacology of CP-945,598, a potent and selective cannabinoid CB1 receptor antagonist for the management of obesity. Biochem.Biophys.Res.Commun. 394 366 PMID: 20211605
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Keywords: CP 945598 hydrochloride, CP 945598 hydrochloride supplier, CP945598, cannabinoid, receptors, cb1, antagonists, pfizer, CB1, Receptors, 4236, Tocris Bioscience
1 Citation for CP 945598 hydrochloride
Citations are publications that use Tocris products. Selected citations for CP 945598 hydrochloride include:
Xiao et al (2018) OXT functions as a spatiotemporal filter for excitatory synaptic inputs to VTA DA neurons. Elife 7 PMID: 29676731
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