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Description: Enhances reprogramming to pluripotency; facilitates telomere maintenance and increases telomere length
Chemical Name: (2E)-2-Butenoic acid
Purity: ≥99% (HPLC)
Biological Activity for Crotonic Acid
Crotonic Acid is an induces histone modifications in chemically induced pluripotent stem cells (CiPSCs). Activates gene expression, facilitates telomere maintenance and increases telomere length, and enhances reprogramming of MEFs to iPSCs using a small molecule cocktail including valproic acid (Cat. No. 2815), CHIR 99021 (Cat. No. 4423), tranylcypromine (Cat. No. 3852), forskolin (Cat. No. 1099), AM 580 (Cat. No. 0760), EPZ 004777 (Cat. No. 5567), SGC 0946 (Cat. No. 4541) and PD 0325901 (Cat. No. 4192).
Technical Data for Crotonic Acid
| M. Wt | 86.09 |
| Formula | C4H6O2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 107-93-7 |
| PubChem ID | 637090 |
| InChI Key | LDHQCZJRKDOVOX-NSCUHMNNSA-N |
| Smiles | C/C=C/C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Crotonic Acid
References for Crotonic Acid
References are publications that support the biological activity of the product.
Fu et al (2018) Dynamics of telomere rejuvenation during chemical induction to pluripotent stem cells. Stem Cell Reports 11 70 PMID: 29861168
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
- Reprogramming
- Organoid Generation
- GMP and Ancillary Material Grade Products
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.