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CST 626

Cat. No. 8021 Submit a Review Datasheet / COA / SDS
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Description: Potent pan IAP Degrader (PROTAC®)
Chemical Name: (2S,4S)-1-((S)-2-Cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-4-(3-((5-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-5-oxopentyl)oxy)phenoxy)-N-((R)-1,2,3,4-tetrahydronaphthalen-1-yl)pyrrolidine-2-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for CST 626

CST 626 is a potent IAP Degrader (PROTAC®) (DC50 values at 16 hours are 0.7 nM, 2.4 nM and 6.2 nM at XIAP, cIAP1 and cIAP2 respectively; Dmax = 90-99%). Reduces cell viability in some cell types, including SUDHL6 and MOLM13 (IC50 values are 16 nM and 21 nM respectively).

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data for CST 626

M. Wt 1103.43
Formula C61H82N8O9S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 3033993-13-1
InChI Key SMENADKMMXTZAZ-FMVATYOPSA-N
Smiles O=C([C@H]1N(C([C@H](C2CCCCC2)NC([C@H](C)NC)=O)=O)C[C@@H](OC3=CC(OCCCCC(N[C@H](C(N4C[C@H](O)C[C@H]4C(N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)=O)=O)C(C)(C)C)=O)=CC=C3)C1)N[C@@H]7CCCC8=CC=CC=C87

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CST 626

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 110.34 100

Preparing Stock Solutions for CST 626

The following data is based on the product molecular weight 1103.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.91 mL 4.53 mL 9.06 mL
5 mM 0.18 mL 0.91 mL 1.81 mL
10 mM 0.09 mL 0.45 mL 0.91 mL
50 mM 0.02 mL 0.09 mL 0.18 mL

Molarity Calculator

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Reconstitution Calculator

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References for CST 626

References are publications that support the biological activity of the product.

Ng et al (2023) Heterobifunctional ligase recruiters enable pan-degradation of inhibitor of apoptosis proteins. J.Med.Chem. 66 4703 PMID: 36996313

If you know of a relevant reference for CST 626, please let us know.

View Related Products by Target

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Citations for CST 626

Citations are publications that use Tocris products.

Currently there are no citations for CST 626. Do you know of a great paper that uses CST 626 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia