Inhibitor of Apoptosis

The inhibitor of apoptosis (IAP) family of proteins are major regulators of apoptosis through interaction with components of the apoptotic signaling cascades. Discovered in baculovirus, human homologs can be described as baculovirus IAP repeat containing (BIRC) proteins.

Products

Background

Literature (1)

Pathways (1)

Gene Data

Inhibitor of Apoptosis Inhibitors
Cat. No.	Product Name / Activity
8018	142D6 New
	Potent Lys-covalent pan-IAP inhibitor
6470	A 410099.1
	High affinity XIAP antagonist; active in vivo
5141	AZD 5582 dihydrochloride
	Dimeric Smac mimetic; potent IAP inhibitor
6491	YM 155
	Survivin suppressor
Ligands
Cat. No.	Product Name / Activity
8069	XIAP Tracer mF-Smac New
	Fluorescein labeled XIAP ligand for TR-FRET assay development
Degraders
Cat. No.	Product Name / Activity
8021	CST 626
	Potent pan IAP Degrader (PROTAC^®)
Other
Cat. No.	Product Name / Activity
3253	Triptolide
	Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive

Related Targets

Caspases

Mitochondria Dyes and Probes

Inhibitors of apoptosis (IAP) are a family of proteins that are the major regulators of apoptosis through their interaction with the various components of the apoptotic signaling cascades. Originally discovered in baculovirus, the human homologs are sometimes described as baculovirus IAP repeat containing (BIRC) proteins.

There are a number of different IAPs including neuronal apoptosis inhibitory protein (NAIP or BIRC1), cellular IAPs (c-IAP-1 and c-IAP-2, or BIRC2 and BIRC3 respectively), X-chromosome linked IAP (XIAP or BIRC4) and survivin (BIRC5). cIAP-1 and 2 function through interaction with TNF receptors and by binding to the mitochondrial protein, SMAC, preventing it binding to XIAP. Thought to be the most potent apoptosis suppressor, XIAP, directly binds and inhibits caspases -3, -7 and -9. Survivin, which also binds to several caspases, is up-regulated in many tumor cell types.

Literature for Inhibitor of Apoptosis

Tocris offers the following scientific literature for Inhibitor of Apoptosis to showcase our products. We invite you to request* your copy today!

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Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Inhibitor of Apoptosis

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.