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CST 967

Cat. No. 7801 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective USP7 Degrader (PROTAC®)
Chemical Name: 3-(1-(1-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidine-4-carbonyl)piperidin-4-yl)-N-(3-((4-hydroxy-1-((R)-3-phenylbutanoyl)piperidin-4-yl)methyl)-4-oxo-3,4-dihydroquinazolin-7-yl)propanamide
Purity: ≥96% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for CST 967

CST 967 is a potent and selective ubiquitin specific protease 7 (USP7) Degrader (PROTAC®; Dmax = 85% at 1μM, DC50 = 17 nM).

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data for CST 967

M. Wt 927.07
Formula C51H58N8O9
Storage Store at -20°C
Purity ≥96% (HPLC)
PubChem ID 170836153
InChI Key REPLCRNGGWSKTN-JYQLQLLISA-N
Smiles O=C1CCC(C(N1)=O)N2C(C3=C(C2=O)C=CC(N4CCC(CC4)C(N5CCC(CC5)CCC(NC6=CC(N=CN7CC8(CCN(CC8)C(C[C@H](C9=CC=CC=C9)C)=O)O)=C(C=C6)C7=O)=O)=O)=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CST 967

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 92.71 100

Preparing Stock Solutions for CST 967

The following data is based on the product molecular weight 927.07. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.08 mL 5.39 mL 10.79 mL
5 mM 0.22 mL 1.08 mL 2.16 mL
10 mM 0.11 mL 0.54 mL 1.08 mL
50 mM 0.02 mL 0.11 mL 0.22 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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References for CST 967

References are publications that support the biological activity of the product.

Murgai et al (2022) Targeting the deubiquitinase USP7 for degradation with PROTACs. Chem.Commun. 58 8858 PMID: 35852517

If you know of a relevant reference for CST 967, please let us know.

View Related Products by Target

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Citations for CST 967

Citations are publications that use Tocris products.

Currently there are no citations for CST 967. Do you know of a great paper that uses CST 967 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia