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Submit ReviewCTCE 9908
Description: CXCR4 antagonist; antitumor
Purity: ≥95% (HPLC)
Biological Activity for CTCE 9908
CTCE 9908 is a CXCR4 antagonist; induces mitotic catastrophe in ovarian cancer cells. Displays additive cytotoxic effects when given with taxol (Cat. No. 1097). Enhances the efficacy of docetaxel (Cat. No. 4056) in a mouse model.
Technical Data for CTCE 9908
| M. Wt | 1927.27 |
| Formula | C86H147N27O23 |
| Sequence |
KGVSLSYRK KGVSLSYR* (Modifications: Amide bridge = 9-8*, Lys-9 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 1030384-98-5 |
| PubChem ID | 90489012 |
| InChI Key | VUYRSKROGTWHDC-ICWZLGNASA-N |
| Smiles | [H]N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCCCCC(NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](N[H])CCCCN)C(C)C)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CTCE 9908
| Solubility | Soluble to 2 mg/ml in water |
Product Datasheets for CTCE 9908
References for CTCE 9908
References are publications that support the biological activity of the product.
Kwong et al (2009) An antagonist of the chemokine receptor CXCR4 induces mitotic catastrophe in ovarian cancer cells. Mol.Cancer Ther. 8 1893 PMID: 19567818
Hassan et al (2011) CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or doce. in a transgenic mouse model. Int.J.Cancer. 129 225 PMID: 20830712
Faber et al (2007) The many facets of SDF-1alpha, CXCR4 agonists and antagonists on hematopoietic progenitor cells. J.Biomed.Biotechnol. 2007 26065 PMID: 17541466
If you know of a relevant reference for CTCE 9908, please let us know.
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Keywords: CTCE 9908, CTCE 9908 supplier, CTCE9908, CXCR4, receptor, chemokines, antagonists, ovarian, cancer, mitotic, catastrophe, mitosis, Mitosis, Chemokine, CXC, Receptors, 5130, Tocris Bioscience
1 Citation for CTCE 9908
Citations are publications that use Tocris products. Selected citations for CTCE 9908 include:
Ludger et al (2020) Microtiter plate-based antibody-competition assay to determine binding affinities and plasma/blood stability of CXCR4 ligands. Sci Rep 10 16036 PMID: 32994431
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