Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewCTPI 2
Description: Selective mitochondrial citrate transporter (SLC25A1) inhibitor
Chemical Name: 2-[[(4-Chloro-3-nitrophenyl)sulfonyl]amino]benzoic acid
Purity: ≥98% (HPLC)
Biological Activity for CTPI 2
CTPI 2 is a selective mitochondrial citrate transporter (SLC25A1) inhibitor with a KD of 3.5 μM. CTPI 2 inhibits the proliferation of H1299 cells in a SLC25A1-dependent manner. It also re-sensitizes T1, T2, and T4 cells to Cisplatin (Cat. No. 2251). CTPI 2 inhibits tumor growth in in vivo models of non-small cell lung cancer (NSCLC). In high-fat diet fed mice CTPI 2 regulates glycolysis, prevents steatohepatitis and normalizes glucose tolerance and insulin sensitivity. CTPI 2 influences the inflammatory pathway by inhibiting IL-6 and TNFα production and M1 macrophage polarization.
Technical Data for CTPI 2
| M. Wt | 356.74 |
| Formula | C13H9ClN2O6S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 68003-38-3 |
| InChI Key | NJTHPOSQGFJTDP-UHFFFAOYSA-N |
| Smiles | O=C(O)C=1C=CC=CC1NS(=O)(=O)C2=CC=C(Cl)C(=C2)N(=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CTPI 2
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.67 | 100 | |
| ethanol | 7.13 | 20 |
Preparing Stock Solutions for CTPI 2
The following data is based on the product molecular weight 356.74. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.8 mL | 14.02 mL | 28.03 mL |
| 5 mM | 0.56 mL | 2.8 mL | 5.61 mL |
| 10 mM | 0.28 mL | 1.4 mL | 2.8 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for CTPI 2
References for CTPI 2
References are publications that support the biological activity of the product.
Tan et al (2020) Inhibition of the mitochondrial citrate carrier, Slc25a1, reverts steatosis, glucose intolerance, and inflammation in preclinical models of NAFLD/NASH. Cell Death Differ. 27 2143 PMID: 31959914
Fernandez et al (2018) The mitochondrial citrate carrier, SLC25A1, drives stemness and therapy resistance in non-small cell lung cancer. Cell Death Differ. 25 1239 PMID: 29651165
Batchuluun et al (2022) Lipogenesis inhibitors: therapeutic opportunities and challenges. Nat.Rev.Drug Discov. 21 283 PMID: 35031766
If you know of a relevant reference for CTPI 2, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: CTPI 2, CTPI 2 supplier, CTPI-2, selective, inhibitor, inhibits, mitochondrial, citrate, transporter, SLC25A1, steatohepatitis, glycolysis, carrier, Other, Ion, Pumps/Transporters, 7794, Tocris Bioscience
Citations for CTPI 2
Citations are publications that use Tocris products.
Currently there are no citations for CTPI 2. Do you know of a great paper that uses CTPI 2 from Tocris? Please let us know.
Reviews for CTPI 2
There are currently no reviews for this product. Be the first to review CTPI 2 and earn rewards!
Have you used CTPI 2?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image