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Submit ReviewCVT 313
Description: Cdk2 and cdk5 inhibitor
Chemical Name: 2,2'-[[6-[[(4-Methoxyphenyl)methyl]amino]-9-(1-methylethyl)-9H-purin-2-yl]imino]bis[ethanol]
Purity: ≥98% (HPLC)
Biological Activity for CVT 313
CVT 313 is a cyclin-dependent kinase 2 (cdk2) inhibitor (reported IC50 values are 0.18 to 0.5 μM). Also inhibits cdk5 in sub-micromolar range (IC50 = 0.42 μM). Displays >7-fold selectivity for cdk2 and cdk5 over other cdks. Inhibits proliferation rat neonatal aortic smooth muscle cells and a range of tumor cells lines in vitro. Inhibits restenosis in a rat carotid artery injury model.
Compound Libraries for CVT 313
CVT 313 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for CVT 313
| M. Wt | 400.47 |
| Formula | C20H28N6O3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 199986-75-9 |
| PubChem ID | 6918386 |
| InChI Key | NQVIIUBWMBHLOZ-UHFFFAOYSA-N |
| Smiles | COC1=CC=C(C=C1)CNC2=NC(N(CCO)CCO)=NC3=C2N=CN3C(C)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CVT 313
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.05 | 100 | |
| ethanol | 40.05 | 100 |
Preparing Stock Solutions for CVT 313
The following data is based on the product molecular weight 400.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.5 mL | 12.49 mL | 24.97 mL |
| 5 mM | 0.5 mL | 2.5 mL | 4.99 mL |
| 10 mM | 0.25 mL | 1.25 mL | 2.5 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
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Product Datasheets for CVT 313
References for CVT 313
References are publications that support the biological activity of the product.
Brooks et al (1997) CVT-313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation. J.Biol.Chem. 272 29207 PMID: 9360999
Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987
If you know of a relevant reference for CVT 313, please let us know.
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Keywords: CVT 313, CVT 313 supplier, CVT313, cdk2, cyclin, dependent, kinase, 2, inhibitors, inhibits, neointimal, proliferation, restenosis, Cyclin-dependent, Kinase, Non-selective, CDKs, 6174, Tocris Bioscience
1 Citation for CVT 313
Citations are publications that use Tocris products. Selected citations for CVT 313 include:
Musa et al (2019) Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes. Nat Commun 10 4128 PMID: 31511524
Do you know of a great paper that uses CVT 313 from Tocris? Please let us know.
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