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Submit ReviewCYM 50769
Description: Novel non-peptide NPBWR1 antagonist
Alternative Names: ML250
Chemical Name: 5-Chloro-2-(9H-fluoren-9-yl)-4-(4-methoxyphenoxy)-3(2H)-pyridazinone
Purity: ≥98% (HPLC)
Biological Activity for CYM 50769
CYM 50769 is a novel non-peptide antagonist of neuropeptide W/B receptor 1 (NPBWR1, GPR7) (IC50 = 0.12 μM).
Technical Data for CYM 50769
| M. Wt | 416.86 |
| Formula | C24H17ClN2O3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1421365-63-0 |
| PubChem ID | 50904505 |
| InChI Key | QHVSQUYCVUHYKT-UHFFFAOYSA-N |
| Smiles | ClC(C=N4)=C(OC5=CC=C(OC)C=C5)C(N4C2C3=C(C=CC=C3)C1=CC=CC=C12)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CYM 50769
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.69 | 100 |
Preparing Stock Solutions for CYM 50769
The following data is based on the product molecular weight 416.86. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.4 mL | 11.99 mL | 23.99 mL |
| 5 mM | 0.48 mL | 2.4 mL | 4.8 mL |
| 10 mM | 0.24 mL | 1.2 mL | 2.4 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
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Product Datasheets for CYM 50769
References for CYM 50769
References are publications that support the biological activity of the product.
Guerrero et al (2013) SAR analysis of novel non-peptidic NPBWR1 (GPR7) antagonists. Bioorg.Med.Chem.Lett. 23 614 PMID: 23287738
If you know of a relevant reference for CYM 50769, please let us know.
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Keywords: CYM 50769, CYM 50769 supplier, NPBWR1, antagonists, neuropeptide, B, W, receptor, 1, CYM50769, ML250, GPR7, Other, Peptide, Receptors, 4948, Tocris Bioscience
Citations for CYM 50769
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.