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Submit ReviewCyprodime hydrochloride
Description: Selective μ antagonist
Chemical Name: 17-(Cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for Cyprodime hydrochloride
Cyprodime hydrochloride is a selective μ-opioid receptor antagonist (Ki values are 5.4, 244.6 and 2187 nM for μ-, δ- and κ-opioid receptors respectively). Reduces levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease.
Technical Data for Cyprodime hydrochloride
| M. Wt | 391.93 |
| Formula | C22H29NO3.HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2387505-50-0 |
| PubChem ID | 71628324 |
| InChI Key | MMOBYZBXXHEAAX-NCBCLDNOSA-N |
| Smiles | O=C3C[C@]24C1=C(OC)C=CC=C1C[C@@H](N(CC5CC5)CC4)[C@@](OC)2CC3.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Cyprodime hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.19 | 100 | |
| ethanol | 39.19 | 100 |
Preparing Stock Solutions for Cyprodime hydrochloride
The following data is based on the product molecular weight 391.93. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.55 mL | 12.76 mL | 25.51 mL |
| 5 mM | 0.51 mL | 2.55 mL | 5.1 mL |
| 10 mM | 0.26 mL | 1.28 mL | 2.55 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.51 mL |
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Product Datasheets for Cyprodime hydrochloride
References for Cyprodime hydrochloride
References are publications that support the biological activity of the product.
Schmidhammer et al (1995) Synthesis and biological evaluation of 14-alkoxymorphinans. 11. 3-hydroxycyprodime and analogues: opioid antagonist profile in comparison to cyprodime. J.Med.Chem. 38 3071 PMID: 7636870
Marki et al (1999) μ-opioid receptor specific antagonist cyprodime: characterization by in vitro radioligand and [35S]GTPγs binding assays. Eur.J.Pharmacol. 383 209 PMID: 10585536
Henry et al (2001) μ- and δ-opioid receptor antagonists reduce levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease. Exp.Neurol. 171 139 PMID: 11520128
If you know of a relevant reference for Cyprodime hydrochloride, please let us know.
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Keywords: Cyprodime hydrochloride, Cyprodime hydrochloride supplier, Selective, μ-opioid, mu-opioid, antagonists, MOP, Receptors, OP3, 118111-54-9, Mu, Opioid, 2601, Tocris Bioscience
2 Citations for Cyprodime hydrochloride
Citations are publications that use Tocris products. Selected citations for Cyprodime hydrochloride include:
Lee et al (2012) Prostatic relaxation induced by loperamide is reduced in spontaneously hypertensive rats. J Neurosci 2012 941685 PMID: 22645476
Norris et al (2019) The Bivalent Rewarding and Aversive properties of δ9-tetrahydrocannabinol are Mediated Through Dissociable Opioid Receptor Substrates and Neuronal Modulation Mechanisms in Distinct Striatal Sub-Regions. Sci Rep 9 9760 PMID: 31278333
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