Cysmethynil

Cat. No. 7337 Submit a Review Datasheet / COA / SDS

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Description: ICMT inhibitor; arrests cell-cycle at G₁ phase

Chemical Name: 5-(3-Methylphenyl)-1-octyl-1H-indole-3-acetamide

Purity: ≥98% (HPLC)

Datasheet

Citations

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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Cysmethynil

Cysmethynil is an isoprenylcysteine carboxylmethyltransferase (ICMT) inhibitor (IC₅₀ = 2.4 μM). Cysmethynil reduces growth of RAS-mutant cell lines in vitro and in vivo (EC₅₀ = 20 μM) and reduces cell viability in a variety of cell lines (IC₅₀ = 16.8-23.3 μM). Tumor growth, mTOR signaling and cell proliferation are inhibited by cysmethynil; apoptosis is induced. Cysmethynil increases p27 and p21 proteins and arrests cell-cycle at the G₁ phase.

Technical Data for Cysmethynil

M. Wt	376.54
Formula	C₂₅H₃₂N₂O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	851636-83-4
PubChem ID	6918831
InChI Key	QIXBOOVPFRZHQQ-UHFFFAOYSA-N
Smiles	CCCCCCCCN1C=C(C2=CC(C3=CC(C)=CC=C3)=CC=C12)CC(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Cysmethynil

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	37.65	100
	DMSO	18.83	50

Preparing Stock Solutions for Cysmethynil

The following data is based on the product molecular weight 376.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.66 mL	13.28 mL	26.56 mL
5 mM	0.53 mL	2.66 mL	5.31 mL
10 mM	0.27 mL	1.33 mL	2.66 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

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Product Datasheets for Cysmethynil

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for Cysmethynil

References are publications that support the biological activity of the product.

Moore et al (2020) RAS-targeted therapies: is the undruggable drugged? Nat.Rev.Drug Discov. 19 533 PMID: 32528145

Manu et al (2017) Inhibition of isoprenylcysteine carboxylmethyltransferase induces cell-cycle arrest and apoptosis through p21 and p21-regulated BNIP3 induction in pancreatic cancer. Mol.Cancer Ther. 16 914 PMID: 28167504

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Citations for Cysmethynil

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