Home / Pharmacology / Enzymes / Kinases / Receptor Interacting Protein Kinase Family / LRRK2 / LRRK2 Inhibitors / CZC 25146

CZC 25146

Cat. No. 6071 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent LRRK2 inhibitor
Chemical Name: N-[2-[[5-Fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for CZC 25146

CZC 25146 is a potent LRRK2 inhibitor (IC50 values are 4.76 and 6.87 nM for for wild-type and G2019S mutant forms of LRRK2, respectively). Also inhibits PLK4, GAK, TNK1, CAMKK2 and PIP4K2. Attenuates mutant LRRK2-induced injury of cultured rodent and human neurons. Cell permeable.

Compound Libraries for CZC 25146

CZC 25146 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for CZC 25146

M. Wt 488.54
Formula C22H25FN6O4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1191911-26-8
PubChem ID 44252884
InChI Key XXHHOTZUJIXPJX-UHFFFAOYSA-N
Smiles FC1=C(NC2=CC=CC=C2NS(C)(=O)=O)N=C(NC3=C(OC)C=C(N4CCOCC4)C=C3)N=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CZC 25146

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 48.85 100

Preparing Stock Solutions for CZC 25146

The following data is based on the product molecular weight 488.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.05 mL 10.23 mL 20.47 mL
5 mM 0.41 mL 2.05 mL 4.09 mL
10 mM 0.2 mL 1.02 mL 2.05 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

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Product Datasheets for CZC 25146

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for CZC 25146

References are publications that support the biological activity of the product.

Ramsden et al (2011) Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons. ACS Chem.Biol. 6 1021 PMID: 21812418

If you know of a relevant reference for CZC 25146, please let us know.

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Citations for CZC 25146

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Currently there are no citations for CZC 25146. Do you know of a great paper that uses CZC 25146 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.