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Submit Review(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin
Description: Selective vasopressin V1A antagonist
Purity: ≥95% (HPLC)
Biological Activity for (d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin
(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin is a selective vasopressin V1A receptor antagonist. Inhibits vasopressin and oxytocin-induced increases in intracellular calcium concentrations in vitro (IC50 values are 5 and 30 nM respectively). Exhibits potent and prolonged antivasopressor activity and induces anxiolytic-like effects in the dorsal, but not ventral, hippocampus in vivo.
Technical Data for (d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin
| M. Wt | 1151.38 |
| Formula | C52H74N14O12S2 |
| Sequence |
XYFQNCPRG (Modifications: X = Pmp, Tyr-2 = Tyr(Me), Disulfide bridge: 1-6, Gly-9 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 73168-24-8 |
| PubChem ID | 122173055 |
| InChI Key | QVQOGNOOAMQKCE-LOVRMFBOSA-N |
| Smiles | COC1=CC=C(C[C@@H]2NC(=O)CC3(CCCCC3)SSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC3=CC=CC=C3)NC2=O)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for (d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin
| Solubility | Soluble to 2 mg/ml in water |
Product Datasheets for (d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin
References for (d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin
References are publications that support the biological activity of the product.
Kruszynski et al (1980) [1-(β-mercapto-β,β-cyclopentamethylenepropionic acid),2-(O-methyl)tyrosine]arginine-vasopressin and [1-(β-mercapto-β,β-cyclopentamethylenepropionic acid)]arginine-vasopressin, two highly potent antagonists of the vas J.Med.Chem. 23 364 PMID: 6892930
Spath et al (1996) Arginine vasopressin and oxyt. increase intracellular calcium and cAMP in human glomerular epithelial cells in culture. Kidney Blood Press.Res. 19 81 PMID: 8871886
Tsuchiya et al (2002) Vasopressin inhibits sarcolemmal ATP-sensitive K+ channels via V1 receptors activation in the guinea pig heart. Circ.J. 66 277 PMID: 11922278
Engin and Treit (2008) Dissociation of the anxiolytic-like effects of Avpr1a and Avpr1b receptor antagonists in the dorsal and ventral hippocampus. Neuropeptides 42 411 PMID: 18508119
If you know of a relevant reference for (d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin, please let us know.
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Keywords: (d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin, (d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin supplier, Selective, vasopressin, V1A, antagonists, V2, Receptors, Vasopressin, 3377, Tocris Bioscience
1 Citation for (d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin
Citations are publications that use Tocris products. Selected citations for (d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin include:
Campos-Lira et al (2019) Dynamic Modulation of Mouse Locus Coeruleus Neurons by Vasopressin 1a and 1b Receptors. Front Neurosci 12 919 PMID: 30618551
Do you know of a great paper that uses (d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin from Tocris? Please let us know.
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.