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Submit Review(D)-(+)-Neopterin is a precursor of biopterin synthesis. Synthesized in response to interferon-γ stimulation; used as a marker of T helper cell-induced immune activation. Also an indicator of oxidative stress; modulates the effects of reactive oxygen species (ROS).
(D)-(+)-Neopterin is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.
M. Wt | 253.21 |
Formula | C9H11N5O4 |
Storage | Store at -20°C |
Purity | ≥98% (HPLC) |
CAS Number | 2009-64-5 |
PubChem ID | 448839 |
InChI Key | BMQYVXCPAOLZOK-XINAWCOVSA-N |
Smiles | OC[C@@H](O)[C@@H](O)C2=NC1=C(N=C2)N=C(N)NC1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Murr et al (2002) Neopterin as a marker for immune system activation. Curr.Drug Metab. 3 175 PMID: 12003349
Huber et al (1984) Immune response-associated production of neopterin. J.Exp.Med. 160 310 PMID: 6429267
Keywords: (D)-(+)-Neopterin, (D)-(+)-Neopterin supplier, cytokines, IFN-gamma, IFN-g, IFN-γ, immune, markers, oxidative, stress, indicators, Cytokines, 4656, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for (D)-(+)-Neopterin include:
Kaminska et al (2016) Highly efficient SERS-based detection of cerebrospinal fluid neopterin as a diagnostic marker of bacterial infection. J Neurochem 408 4319 PMID: 27086021
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.