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Submit Reviewδ9-Tetrahydrocannabinol
Description: Cannabinoid receptor agonist; psychoactive
Alternative Names: THC
Chemical Name: (6aR,10aR)-6a,7,8,10a-Tetrahydro-6,6,9-trimethyl-3-pentyl-6H-dibenzo[b,d]pyran-1-ol
Purity: ≥95% (HPLC)
Biological Activity for δ9-Tetrahydrocannabinol
Cannabinoid receptor agonist (Ki values are 5.05 and 3.13 nM for CB1 and CB2 receptors respectively; EC50 values are 6, 0.4 and 8 nM at CB1, CB2 and GPR55 receptors respectively). Major psychoactive constituent of marijuana. Shown to inhibit lung cancer growth and metastasis in an in vivo mouse model.
Technical Data for δ9-Tetrahydrocannabinol
| M. Wt | 314.46 |
| Formula | C21H30O2 |
| Storage | Store at RT |
| Purity | ≥95% (HPLC) |
| CAS Number | 1972-08-3 |
| Smiles | CCCCCC1=CC3=C([C@]2([H])C=C(C)CC[C@]([H])2C(C)(C)O3)C(O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for δ9-Tetrahydrocannabinol
References for δ9-Tetrahydrocannabinol
References are publications that support the biological activity of the product.
Ryberg et al (2007) The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 152 1092 PMID: 17876302
Pertwee (2008) The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin. Br.J.Pharmacol. 153 199 PMID: 17828291
Preet et al (2008) Δ9-tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo. Oncogene 27 339 PMID: 17621270
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Citations for δ9-Tetrahydrocannabinol
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Currently there are no citations for δ9-Tetrahydrocannabinol.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.