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Description: Endogenous CB1 agonist
Alternative Names: Docosatetraenylethanolamide
Chemical Name: N-(2-Hydroxyethyl)-7Z,10Z,13Z,16Z-docosatetraenamide
Biological Activity for DEA
DEA is a potent endocannabinoid and anandamide (Cat. No. 1339) analog that activates CB1 receptors in microglia and binds to rat synaptosomal membranes (Ki = 34.4 nM). Cannabimimetic in vivo.
Technical Data for DEA
| M. Wt | 375.59 |
| Formula | C24H41NO2 |
| Storage | Desiccate at -20°C |
| CAS Number | 150314-35-5 |
| PubChem ID | 5282273 |
| InChI Key | FMVHVRYFQIXOAF-DOFZRALJSA-N |
| Smiles | CCCCC\C=C/C\C=C/C/C=C\C/C=C\CCCCCC(NCCO)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for DEA
References for DEA
References are publications that support the biological activity of the product.
Barg et al (1995) Cannabinomimetic behavioral effects of and adenylate cyclase inhibition by two new endogenous anandamides. Eur.J.Pharmacol. 287 145 PMID: 8749028
Hanus et al (1993) Two new unsaturated fatty acid ethanolamides in brain that bind to the cannabinoid receptor. J.Med.Chem. 36 3032 PMID: 8411021
Walter et al (2001) Microglial cells produce endocannabinoids and express functional cannabinoid receptors: evidence that docosatetraenylethanolamide (DEA) is an additional endocannabinoid. Soc.Neurosci.Abstr. 634.16
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Keywords: DEA, DEA supplier, Endogenous, CB1, agonists, Cannabinoids, Receptors, cb1r, Docosatetraenylethanolamide, 1485, Tocris Bioscience
Citations for DEA
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Currently there are no citations for DEA.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.
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