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Submit ReviewDelavirdine mesylate
Description: Non-nucleoside reverse transcriptase inhibitor
Alternative Names: U 90152
Chemical Name: 1-[3-[(1-Methylethyl)amino]-2-pyridinyl]-4-[[5-[(methylsulfonyl)amino]-1H-indol-2-yl]carbonyl]-piperazine monomethanesulfonate
Purity: ≥99% (HPLC)
Biological Activity for Delavirdine mesylate
Delavirdine mesylate is a non-nucleoside reverse transcriptase inhibitor (NNRTI). Selectively inhibits HIV-1 reverse transcriptase (RNA-dependent DNA polymerase) over other cellular polymerases (IC50 values are 0.26, 440 and >550 μM for HIV-1 reverse transcriptase, DNA polymerase α and DNA polymerase δ). Prevents HIV-1 spread in vivo and blocks viral replication in peripheral blood lymphocytes. Orally active.
Licensing Information
Sold for research purposes under agreement from Viiv.
Compound Libraries for Delavirdine mesylate
Delavirdine mesylate is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Delavirdine mesylate
| M. Wt | 552.67 |
| Formula | C22H28N6O3S.CH3SO3H |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 147221-93-0 |
| PubChem ID | 441386 |
| InChI Key | MEPNHSOMXMALDZ-UHFFFAOYSA-N |
| Smiles | O=C(N3CCN(C4=NC=CC=C4NC(C)C)CC3)C2=CC1=CC(NS(=O)(C)=O)=CC=C1N2.CS(O)(=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Delavirdine mesylate
References for Delavirdine mesylate
References are publications that support the biological activity of the product.
Dueweke et al (1993) U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication. Antimicrob.Agents Chemother. 37 1127 PMID: 7685995
Pagano and Chong (1995) In vitro inhibition of human immunodeficiency virus type 1 by a combination of delavi. (U-90152) with protease inhibitor U-75875 or IF.-alpha. J.Infect.Dis. 171 61 PMID: 7528253
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Keywords: Delavirdine mesylate, Delavirdine mesylate supplier, reverse, transcriptase, inhibitors, inhibits, polymerases, RNA/DNA, antivirals, antiretrovirals, HIV, non-nucleoside, NNRTI, HIV-1, U90152, U, 90152, DNA, Polymerase, 4149, Tocris Bioscience
Citations for Delavirdine mesylate
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Currently there are no citations for Delavirdine mesylate.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.