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Submit Reviewdes-Gln14-Ghrelin (rat)
Description: Endogenous ghrelin receptor ligand
Biological Activity for des-Gln14-Ghrelin (rat)
An endogenous ligand for the ghrelin receptor (GHS-R1a), produced by alternative splicing of the rat ghrelin gene. Potently induces Ca2+ release in cells expressing ghrelin receptors (EC50 = 2.4 nM) and stimulates GH release in vivo.
Licensing Information
This peptide is distributed under license from Dr. Kangawa
Technical Data for des-Gln14-Ghrelin (rat)
| M. Wt | 3186.7 |
| Formula | C142H237N43O40 |
| Sequence |
GSSFLSPEHQKAQRKESKKPPAKLQPR (Modifications: Ser-3 = Ser(n-octanoyl)) |
| Storage | Desiccate at -20°C |
| CAS Number | 293735-04-3 |
| PubChem ID | 90479785 |
| InChI Key | GKDHXLGLEXRRSB-MVILVGDSSA-N |
| Smiles | [H]NCC(=O)N[C@@H](CO)C(=O)N[C@@H](COC(=O)CCCCCCC)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for des-Gln14-Ghrelin (rat)
References for des-Gln14-Ghrelin (rat)
References are publications that support the biological activity of the product.
Hosoda et al (2000) Purification and characterization of rat des-Gln14-ghrelin, a second endogenous ligand for the GH secretagogue receptor. J.Biol.Chem. 275 21995 PMID: 10801861
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Keywords: des-Gln14-Ghrelin (rat), des-Gln14-Ghrelin (rat) supplier, Endogenous, ghrelin, receptor, ligands, GHS-R1a, Receptors, Growth, Hormone, Secretagog, Receptor, 1a, Ghrelin, 1346, Tocris Bioscience
Citations for des-Gln14-Ghrelin (rat)
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