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Submit Review[Des-octanoyl]-Ghrelin (rat)
Description: Major circulating form of ghrelin; devoid of activity at GHS receptor
Alternative Names: Des-acyl ghrelin (rat)
Purity: ≥95% (HPLC)
Biological Activity for [Des-octanoyl]-Ghrelin (rat)
[Des-octanoyl]-Ghrelin (rat) is a non-acylated, major circulating isoform of ghrelin that does not bind to the ghrelin receptor (GHS-R1a), nor induce growth hormone release.
Technical Data for [Des-octanoyl]-Ghrelin (rat)
| M. Wt | 3188.63 |
| Formula | C139H231N45O41 |
| Sequence | GSSFLSPEHQKAQQRKESKKPPAKLQPR |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 307950-60-3 |
| PubChem ID | 90488789 |
| InChI Key | CMCPTGQGZXKKEH-MGXJLMSJSA-N |
| Smiles | [H]NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for [Des-octanoyl]-Ghrelin (rat)
References for [Des-octanoyl]-Ghrelin (rat)
References are publications that support the biological activity of the product.
Bedendi et al (2003) Cardiac effects of ghrelin and its endogenous derivatives des-octanoyl ghrelin and des-Gln14-ghrelin. Eur.J.Pharmacol. 476 87 PMID: 12969753
Thompson et al (2004) Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a GH secretagogue receptor Endocrinology 145 234 PMID: 14551228
Cassoni et al (2004) Expression of ghrelin and biological activity of specific receptors for ghrelin and des-acyl ghrelin in human prostate neoplasms and related cell lines. Eur.J.Endocrinol. 150 173 PMID: 14763915
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Keywords: [des-octanoyl]-Ghrelin (rat), [des-octanoyl]-Ghrelin (rat) supplier, circulating, ghrelin, devoid, activity, GHS-R1a, Receptors, Growth, Hormone, Secretagogue, Receptor, 1a, Ghrelin, Des-acyl, (rat), 2951, Tocris Bioscience
2 Citations for [Des-octanoyl]-Ghrelin (rat)
Citations are publications that use Tocris products. Selected citations for [Des-octanoyl]-Ghrelin (rat) include:
Engel et al (2015) Blockade of GH secretagogue receptor 1A signaling by JMV 2959 attenuates the NMDAR antagonist, phencyclidine-induced impairments in prepulse inhibition. Psychopharmacology (Berl) 232 4285 PMID: 26319159
Kemp et al (2011) Intrarenal ghrelin infusion stimulates distal nephron-dependent sodium reabsorption in normal rats. Br J Pharmacol 57 633 PMID: 21220707
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Literature in this Area
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.