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Submit ReviewDesmopressin
Description: Synthetic vasopressin analog; V1B and V2 agonist
Purity: ≥95% (HPLC)
Biological Activity for Desmopressin
Desmopressin is a synthetic vasopressin analog that acts as an agonist at V1B and V2 receptors (EC50 values are 11.4 and 23.9 nM and Ki values are 5.84 and 65.9 nM respectively). Prevents polycystic kidney disease formation and exhibits antidiuretic, antiproliferative, hemostatic and hypotensive activity in vivo.
Technical Data for Desmopressin
| M. Wt | 1069.22 |
| Formula | C46H64N14O12S2 |
| Sequence |
XYFQNCPRG (Modifications: X = Mpr, Arg-8 = D-Arg, Gly-9 = C-terminal amide, Cyclized = X-1 - Cys-6) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 16679-58-6 |
| PubChem ID | 5311065 |
| InChI Key | NFLWUMRGJYTJIN-PNIOQBSNSA-N |
| Smiles | NC(=O)CC[C@@H]1NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)CCSSC[C@H](NC(=O)[C@H](CC(N)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](CCCNC(N)=N)C(=O)NCC(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Desmopressin
| Solubility | Soluble to 4 mg/ml in water |
Product Datasheets for Desmopressin
References for Desmopressin
References are publications that support the biological activity of the product.
Saito et al (1997) 1-Desamino-8-D-arginine vasopressin (DDAVP) as an agonist on V1b vasopressin receptor. Biochem.Pharmacol. 53 1711 PMID: 9264324
Gomez et al (2006) Desmopressin and other synthetic vasopressin analogues in cancer treatment. Bull.Cancer 93 E7 PMID: 16517412
Torres (2008) Vasopressin antagonists in polycystic kidney disease. Semin.Nephrol. 28 306 PMID: 18519091
If you know of a relevant reference for Desmopressin, please let us know.
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Keywords: Desmopressin, Desmopressin supplier, Synthetic, vasopressin, analog, V1B, V2, agonists, Receptors, Vasopressin, 3396, Tocris Bioscience
1 Citation for Desmopressin
Citations are publications that use Tocris products. Selected citations for Desmopressin include:
Campos-Lira et al (2019) Dynamic Modulation of Mouse Locus Coeruleus Neurons by Vasopressin 1a and 1b Receptors. Front Neurosci 12 919 PMID: 30618551
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Literature in this Area
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.