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DG 041

Cat. No. 6240 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective EP3 antagonist; antiplatelet and antithrombotic
Chemical Name: (2E)-3-[1-[(2,4-Dichlorophenyl)methyl]-5-fluoro-3-methyl-1H-indol-7-yl]-N-[(4,5-dichloro-2-thienyl)sulfonyl]-2-propenamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for DG 041

DG 041 is a potent and selective EP3 antagonist (IC50 = 4.6 nM). Inhibits PGE2 facilitation of platelet aggregation in vitro and ex vivo. Displays good plasma and metabolic stability. Does not affect bleeding time in rats. Antiplatelet and antithrombotic.

Technical Data for DG 041

M. Wt 592.32
Formula C23H15Cl4FN2O3S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 861238-35-9
PubChem ID 11296282
InChI Key BFBTVZNKWXWKNZ-HWKANZROSA-N
Smiles CC1=CN(C2=C(C=C(C=C12)F)/C=C/C(NS(=O)(C3=CC(Cl)=C(S3)Cl)=O)=O)CC4=C(C=C(C=C4)Cl)Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DG 041

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 59.23 100

Preparing Stock Solutions for DG 041

The following data is based on the product molecular weight 592.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.69 mL 8.44 mL 16.88 mL
5 mM 0.34 mL 1.69 mL 3.38 mL
10 mM 0.17 mL 0.84 mL 1.69 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

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References for DG 041

References are publications that support the biological activity of the product.

Markovič et al (2017) Structural features of subtype-selective EP receptor modulators. Drug Discov.Today. 22 57 PMID: 27506873

Singh et al (2009) Antagonists of the EP3 receptor for prostaglandin E2 are novel antiplatelet agents that do not prolong bleeding. ACS Chem.Biol. 4 115 PMID: 19193156

If you know of a relevant reference for DG 041, please let us know.

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Keywords: DG 041, DG 041 supplier, DG041, potent, selective, EP3, antagonists, Receptors, Prostanoid, prostaglandins, prostacyclins, eicosanoids, 6240, Tocris Bioscience

1 Citation for DG 041

Citations are publications that use Tocris products. Selected citations for DG 041 include:

Dieter et al (2016) Aspirin prevents colorectal cancer metastasis in mice by splitting the crosstalk between platelets and tumor cells. Oncotarget 7 32462-77 PMID: 27074574

Do you know of a great paper that uses DG 041 from Tocris? Please let us know.

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