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DH 97

Cat. No. 1218 2 Citations Submit a Review Datasheet / COA / SDS
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Description: MT2 receptor antagonist
Chemical Name: N-Pentanoyl-2-benzyltryptamine
Datasheet
Citations (2)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for DH 97

DH 97 is a relatively potent MT2 melatonin receptor antagonist (pKi value = 8.03), displaying 89- and 229-fold selectivity over MT1 and GPR50 (melatonin-related orphan receptor) respectively.

Technical Data for DH 97

M. Wt 334.46
Formula C22H26N2O
Storage Store at RT
CAS Number 220339-00-4
PubChem ID 3467177
InChI Key HDOIPCLEKCEANF-UHFFFAOYSA-N
Smiles CCCCC(=O)NCCC1=C(CC2=CC=CC=C2)NC2=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DH 97

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 100

Preparing Stock Solutions for DH 97

The following data is based on the product molecular weight 334.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.99 mL 14.95 mL 29.9 mL
5 mM 0.6 mL 2.99 mL 5.98 mL
10 mM 0.3 mL 1.49 mL 2.99 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

Molarity Calculator

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Reconstitution Calculator

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References for DH 97

References are publications that support the biological activity of the product.

Teh and Sugden (1998) Comparison of the relationships of melatonin receptor agonists and antagonists; lengthening the N-acyl side chain has differing effects on potency on Xenopus melanophores. Naunyn Schmiedebergs Arch.Pharmacol. 358 522 PMID: 9840420

Ting et al (1999) Molecular and pharmacological evidence for MT1 melatonin receptor subtype in the tail artery of juvenile Wistar rats. Br.J.Pharmacol. 127 987 PMID: 10433507

If you know of a relevant reference for DH 97, please let us know.

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2 Citations for DH 97

Citations are publications that use Tocris products. Selected citations for DH 97 include:

Kojima et al (2011) Melatonin inhibits tachykinin NK2 receptor-triggered 5-HT release from guinea pig isolated colonic mucosa. Br J Pharmacol 162 1179 PMID: 21091649

Sjöblom et al (2003) Melatonin-induced calcium signaling in clusters of human and rat duodenal enterocytes. BMC Neurosci 284 G1034 PMID: 12584110

Do you know of a great paper that uses DH 97 from Tocris? Please let us know.

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