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Submit ReviewDiazoxide
Description: Inhibits AMPA desensitization
Chemical Name: 7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
Purity: ≥98% (HPLC)
Biological Activity for Diazoxide
Diazoxide is an antihypertensive, activates ATP-dependent K+ channels (Kir6). Induces activation of PKCε, an intermediate in the opening of mitoKATP channels, results in cardioprotection against hypoxia-induced death. Blocks desensitization of AMPA receptors.
Compound Libraries for Diazoxide
Diazoxide is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Diazoxide
| M. Wt | 230.67 |
| Formula | C8H7ClN2O2S |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 364-98-7 |
| PubChem ID | 3019 |
| InChI Key | GDLBFKVLRPITMI-UHFFFAOYSA-N |
| Smiles | CC1=NC2=C(C=C(Cl)C=C2)S(=O)(=O)N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Diazoxide
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 23.07 | 100 |
Preparing Stock Solutions for Diazoxide
The following data is based on the product molecular weight 230.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.34 mL | 21.68 mL | 43.35 mL |
| 5 mM | 0.87 mL | 4.34 mL | 8.67 mL |
| 10 mM | 0.43 mL | 2.17 mL | 4.34 mL |
| 50 mM | 0.09 mL | 0.43 mL | 0.87 mL |
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Product Datasheets for Diazoxide
References for Diazoxide
References are publications that support the biological activity of the product.
Kim et al (2006) Dox acts more as a PKC-ε activator, and indirectly activates the mitochondiral KATP channel conferring cardioprotection against hypoxic injury. Br.J.Pharmacol. 149 1059 PMID: 17043673
Trube et al (1986) Opposite effects of tolbut. and Dox on the ATP-dependent K+ channel in mouse pancreatic β-cells. Pflugers Arch. 407 493 PMID: 2431383
Yamada and Rothman (1992) Dox blocks glutamate desensitization and prolongs excitatory postsynaptic currents in rat hippocampal neurons. J.Physiol. 458 409 PMID: 1302270
Merck Index 12 3051
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Keywords: Diazoxide, Diazoxide supplier, Blocks, desensitization, desensitisation, AMPA, receptors, K+, channel, opener, KATP, Glutamate, Receptors, iGlur, Ionotropic, Potassium, KIR, Kir6, Channels, Inward, Rectifier, rectifier, 0964, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Diazoxide, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
4 Citations for Diazoxide
Citations are publications that use Tocris products. Selected citations for Diazoxide include:
Cox et al (2014) Chronic neonatal Dox therapy is not associated with adverse effects J Neurosci 14 49 PMID: 25587244
Niu et al (2011) Sex differences in the contribution of ATP-sensitive K+ channels in trigeminal ganglia under an acute muscle pain condition. Neuroscience 180 344 PMID: 21296645
Frazão et al (2013) Shift in Kiss1 cell activity requires estrogen receptor α. J Neurosci 33 2807 PMID: 23407940
Sun et al (2014) Label-free cell phenotypic profiling decodes the composition and signaling of an endogenous ATP-sensitive potassium channel. Sci Rep 4 4934 PMID: 24816792
Do you know of a great paper that uses Diazoxide from Tocris? Please let us know.
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