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Submit ReviewDJ-V 159
Description: GPRC6A agonist
Chemical Name: N1,N3-Bis(4-cyano-3-(trifluoromethyl)phenyl)isophthalamide
Purity: ≥98% (HPLC)
Biological Activity for DJ-V 159
DJ-V 159 is a GPRC6A agonist. Activates ERK and stimulates cAMP production in GPRC6A expressing HEK-293 cells. Stimulates insulin secretion from mouse β-cells in vitro. Reduces blood glucose levels in mice in vivo.
Technical Data for DJ-V 159
| M. Wt | 502.37 |
| Formula | C24H12F6N4O2 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 2253744-53-3 |
| PubChem ID | 137319717 |
| InChI Key | VEVNLJLJLVESLL-UHFFFAOYSA-N |
| Smiles | O=C(NC1=CC=C(C#N)C(C(F)(F)F)=C1)C2=CC(C(NC3=CC(C(F)(F)F)=C(C#N)C=C3)=O)=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for DJ-V 159
References for DJ-V 159
References are publications that support the biological activity of the product.
Pi et al (2018) Computationally identified novel agonists for GPRC6A. PLoS One 13 e0195980 PMID: 29684031
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Keywords: DJ-V 159, DJ-V 159 supplier, DJ-V159, CPRC6A, agonists, agonism, diabetes, insulin, β, beta, cells, Orphan, 7-TM, Receptors, 6645, Tocris Bioscience
1 Citation for DJ-V 159
Citations are publications that use Tocris products. Selected citations for DJ-V 159 include:
Sheng et al (2023) Substance P aggravates ligature-induced periodontitis in mice. Front Immunol 14 1099017 PMID: 37122730
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