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Submit Review(±)-AC 7954 hydrochloride
Description: Non-peptide UT receptor agonist
Chemical Name: (±)-3-(4-Chlorophenyl)-3-[2-(dimethylamino)ethyl]-3,4-dihydro-1H-2-benzopyran-1-one hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for (±)-AC 7954 hydrochloride
(±)-AC 7954 hydrochloride is a highly selective, non-peptide urotensin-II (UT) receptor agonist that displays potent activity at human and rat UT receptors (pEC50 values are 6.5 and 6.7 respectively).
Technical Data for (±)-AC 7954 hydrochloride
| M. Wt | 366.28 |
| Formula | C19H20ClNO2.HCl |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 477313-09-0 |
| PubChem ID | 9907171 |
| InChI Key | AJPGLOWFIBOGMH-UHFFFAOYSA-N |
| Smiles | Cl.CN(C)CCC1(CC2=CC=CC=C2C(=O)O1)C1=CC=C(Cl)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for (±)-AC 7954 hydrochloride
References for (±)-AC 7954 hydrochloride
References are publications that support the biological activity of the product.
Croston et al (2002) Discovery of the first nonpeptide agonist of the GPR14/urotensin-II receptor: 3-(4-chlorophenyl)-3-(2-(dimethylamino)ethyl)isochroman-1-one (AC-7954). J.Med.Chem. 45 4950 PMID: 12408704
Lavecchia et al (2005) Architecture of the human urotensin II receptor: comparison of the binding domains of peptide and non-peptide urotensin II agonists. J.Med.Chem. 48 2480 PMID: 15801838
Lehmann et al (2006) Novel potent and efficacious nonpeptidic urotensin II receptor agonists. J.Med.Chem. 49 2232 PMID: 16570919
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Keywords: (±)-AC 7954 hydrochloride, (±)-AC 7954 hydrochloride supplier, Non-peptide, UT, receptor, agonists, Receptors, Urotensin-II, (±)-AC7954, hydrochloride, 2484, Tocris Bioscience
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