(±)-Eriodictyol

Discontinued Product

7199 has been discontinued.

View all TRPV Channels products.
Description: Potent TRPV1 antagonist; also antioxidant; activates Nrf2/ARE signaling
Chemical Name: 2-(3,4-Dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for (±)-Eriodictyol

(±)-Eriodictyol is a potent TRPV1 antagonist. Inhibits capsaicin (Cat. No. 0462) -induced Ca2+ influx in synaptosomes. Exhibits antinociceptive activity in animal models without affecting body temperature. Also antioxidant; protects against H2O2-induced neurotoxicity in vitro by activation of Nrf2/ARE signaling. Modeling studies predict binding to ACE2 preventing its interaction with SARS-CoV-2 S protein. Naturally-derived flavonoid. Orally bioavailable.

Technical Data for (±)-Eriodictyol

M. Wt 288.26
Formula C15H12O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 4049-38-1
PubChem ID 11095
InChI Key SBHXYTNGIZCORC-UHFFFAOYSA-N
Smiles OC1=CC(O)=C2C(CC(C3=CC(O)=C(C=C3)O)OC2=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for (±)-Eriodictyol

References for (±)-Eriodictyol

References are publications that support the biological activity of the product.

Smith and Smith et al (2020) Repurposing therapeutics for COVID-19: Supercomputer-based docking to the SARS-CoV-2 viral spike protein and viral spike protein-human ACE2 interface. ChemRxiv - Paper not yet peer reviewed

Rossato et al (2011) Eriodictyol: A flavonoid antagonist of the TRPV1 receptor with antioxidant activity. Biochem.Pharmacol. 81 544 PMID: 21087598

Lou et al (2012) Eriodictyol protects against H2O2-induced neuron-like PC12 cell death through activation of Nrf2/ARE signaling pathway. Neurochem.Int. 61 251 PMID: 22609376

View Related Products by Product Action

View all TRPV Channel Antagonists

Keywords: (±)-Eriodictyol, (±)-Eriodictyol supplier, Transient, receptor, potential, vanilloid, 1, TRPV1, potent, antagonist, antagonists, antagonism, antioxidant, ACE2, ligand, SARS-CoV-2, COVID-19, Nrf2, signaling, activators, activator, activates, TRPV, 7199, Tocris Bioscience

Citations for (±)-Eriodictyol

Citations are publications that use Tocris products.

Currently there are no citations for (±)-Eriodictyol.

Reviews for (±)-Eriodictyol

There are currently no reviews for this product. Be the first to review (±)-Eriodictyol and earn rewards!

Have you used (±)-Eriodictyol?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review