Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit Review(±)-Eriodictyol is a potent TRPV1 antagonist. Inhibits capsaicin (Cat. No. 0462) -induced Ca2+ influx in synaptosomes. Exhibits antinociceptive activity in animal models without affecting body temperature. Also antioxidant; protects against H2O2-induced neurotoxicity in vitro by activation of Nrf2/ARE signaling. Modeling studies predict binding to ACE2 preventing its interaction with SARS-CoV-2 S protein. Naturally-derived flavonoid. Orally bioavailable.
M. Wt | 288.26 |
Formula | C15H12O6 |
Storage | Store at -20°C |
Purity | ≥98% (HPLC) |
CAS Number | 4049-38-1 |
PubChem ID | 11095 |
InChI Key | SBHXYTNGIZCORC-UHFFFAOYSA-N |
Smiles | OC1=CC(O)=C2C(CC(C3=CC(O)=C(C=C3)O)OC2=C1)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Smith and Smith et al (2020) Repurposing therapeutics for COVID-19: Supercomputer-based docking to the SARS-CoV-2 viral spike protein and viral spike protein-human ACE2 interface. ChemRxiv - Paper not yet peer reviewed
Rossato et al (2011) Eriodictyol: A flavonoid antagonist of the TRPV1 receptor with antioxidant activity. Biochem.Pharmacol. 81 544 PMID: 21087598
Lou et al (2012) Eriodictyol protects against H2O2-induced neuron-like PC12 cell death through activation of Nrf2/ARE signaling pathway. Neurochem.Int. 61 251 PMID: 22609376
Keywords: (±)-Eriodictyol, (±)-Eriodictyol supplier, Transient, receptor, potential, vanilloid, 1, TRPV1, potent, antagonist, antagonists, antagonism, antioxidant, ACE2, ligand, SARS-CoV-2, COVID-19, Nrf2, signaling, activators, activator, activates, TRPV, 7199, Tocris Bioscience
Citations are publications that use Tocris products.
Currently there are no citations for (±)-Eriodictyol.
There are currently no reviews for this product. Be the first to review (±)-Eriodictyol and earn rewards!
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image