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Submit Review(±)-McN 5652
Description: Potent, orally active 5-HT uptake inhibitor; also inhibits noradrenalin and dopamine uptake in vitro
Alternative Names: McN 5652-Z
Chemical Name: (6R,10bS)-rel-1,2,3,5,6,10b-Hexahydro-6-[4-(methylthio)phenyl]-pyrrolo[2,1-a]isoquinoline
Purity: ≥98% (HPLC)
Biological Activity for (±)-McN 5652
(±)-McN 5652 is a potent, high affinity serotonin re-uptake inhibitor; selective in vivo. Displays moderate selectivity over noradrenalin and dopamine re-uptake in vitro (Ki values are 0.68, 2.9 and 36.8 nM for inhibition of serotonin, noradrenalin and dopamine uptake respectively in rat brain synaptosomes). Potently potentiates 5-HT-induced effects in vivo following oral administration. Biological activity resides predominantly in the (+)-enantiomer.
Technical Data for (±)-McN 5652
| M. Wt | 295.44 |
| Formula | C19H21NS |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 96795-89-0 |
| PubChem ID | 6336338 |
| InChI Key | YVKDUIAAPBKHMJ-MOPGFXCFSA-N |
| Smiles | [H][C@]23C1=CC=CC=C1[C@@H]([C@]4=CC=C(SC)C=C4)CN2CCC3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for (±)-McN 5652
References for (±)-McN 5652
References are publications that support the biological activity of the product.
Shank et al (1988) McN-5652: a highly potent inhibitor of serotonin uptake. J.Pharmacol.Exp.Ther. 247 1032 PMID: 2905001
Maryanoff et al (1990) Pyrroloisoquinoline antidepressants. 3. A focus on serotonin. J.Med.Chem. 33 2793 PMID: 2213832
Smith et al (1991) Effects of pyrroloisoquinoline enantiomers ((+)- and (-)-McN-5652-Z) on behavioral and pharmacological serotonergic mechanisms in rats. Eur.J.Pharmacol. 196 85 PMID: 1831423
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.