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Submit Review(±)-SLV 319
Description: High affinity and selective CB1 antagonist
Chemical Name: 3-(4-Chlorophenyl)-N-[(4-Chlorophenyl)sulfonyl]-4,5-dihydro-N'-methyl-4-phenyl-1H-pyrazole-1-carboximidamide
Purity: ≥98% (HPLC)
Biological Activity for (±)-SLV 319
(±)-SLV 319 is a high affinity and selective CB1 receptor antagonist (Ki = 7.8 nM). Exhibits 1000-fold selectivity for CB1 over CB2 receptors. Inhibits CP 55,940-induced hypotension and WIN 55,212-2-induced hypothermia in vivo. Orally active.
Technical Data for (±)-SLV 319
| M. Wt | 487.4 |
| Formula | C23H20Cl2N4O2S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 362519-49-1 |
| PubChem ID | 11179267 |
| InChI Key | AXJQVVLKUYCICH-UHFFFAOYSA-N |
| Smiles | ClC(C=C4)=CC=C4C1=NN(/C(NS(C3=CC=C(Cl)C=C3)(=O)=O)=N\C)CC1C2=CC=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for (±)-SLV 319
References for (±)-SLV 319
References are publications that support the biological activity of the product.
Lange et al (2004) Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB1 cannabinoid receptor antagonists. J.Med.Chem. 47 627 PMID: 14736243
Lange et al (2005) Novel 3,4-diarylpyrazolines as potent cannabinoid CB1 receptor antagonists with lower lipophilicity. Bioorg.Med.Chem.Lett. 15 4794 PMID: 16140010
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Citations for (±)-SLV 319
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.
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