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Submit ReviewDMAB-anabaseine dihydrochloride
Discontinued Product
2241 has been discontinued.
Description: Partial agonist at α7 nAChR; also α4β2 antagonist
Chemical Name: 4-[(5,6-Dihydro[2,3'-bipyridin]-3(4H)-ylidene)methyl]-N,N-dimethylbenzenamine dihydrochloride
Purity: ≥98% (HPLC)
Biological Activity for DMAB-anabaseine dihydrochloride
Partial agonist at α7-containing neuronal nicotinic receptors and antagonist at α4β2 and other nicotinic receptors. Displays specific cognition-enhancing effects; improves long-term memory in rats.
Technical Data for DMAB-anabaseine dihydrochloride
| M. Wt | 364.32 |
| Formula | C19H21N3.2HCl |
| Storage | Desiccate at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 154149-38-9 |
| PubChem ID | 16759167 |
| InChI Key | DHCNEWWWKHBASC-YNHPUKFJSA-N |
| Smiles | CN(C)C1=CC=C(/C=C2/C(C3=CN=CC=C3)=NCCC2)C=C1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for DMAB-anabaseine dihydrochloride
References for DMAB-anabaseine dihydrochloride
References are publications that support the biological activity of the product.
Arendash et al (1995) Improved learning and memory in aged rats with chronic administration of the nicotinic receptor agonist GTS-21. Brain Res. 674 252 PMID: 7796104
Kem et al (1997) Anabaseine is a potent agonist on muscle and neuronal alpha-bungarotoxin-sensitive nicotinic receptors. J.Pharmacol.Exp.Ther. 283 979 PMID: 9399967
Stevens et al (1998) Selective alpha7-nicotinic agonists normalize inhibition of auditory response in DBA mice. Psychopharmacology 136 320 PMID: 9600576
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Keywords: DMAB-anabaseine dihydrochloride, DMAB-anabaseine dihydrochloride supplier, Partial, agonists, α7, alpha7-containing, a7, receptors, antagonists, α4β2, a4b2, neuronal, nicotinic, Nicotinic, Receptors, Acetylcholine, nAChR, (a7), (a4b2), 2241, Tocris Bioscience
Citations for DMAB-anabaseine dihydrochloride
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Currently there are no citations for DMAB-anabaseine dihydrochloride.
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Literature in this Area
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