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Submit ReviewDMH4
Description: Selective VEGFR-2 inhibitor
Chemical Name: 6-[4-[2-(4-Morpholinyl)ethoxy]phenyl]-3-phenylpyrazolo[1,5-a]pyrimidine
Purity: ≥98% (HPLC)
Biological Activity for DMH4
DMH4 is a selective VEGFR-2 inhibitor (IC50 values are 161, 3558, 8038 and > 30000 nM for VEGFR-2, BMPR-I, AMPK and TGFβR-I respectively). Displays antiangiogenic activity in vitro and in vivo.
Technical Data for DMH4
| M. Wt | 400.47 |
| Formula | C24H24N4O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 515880-75-8 |
| PubChem ID | 5329447 |
| InChI Key | SKZQZGSPYYHTQG-UHFFFAOYSA-N |
| Smiles | C(C=N2)(C4=CC=C(OCCN5CCOCC5)C=C4)=CN1C2=C(C3=CC=CC=C3)C=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for DMH4
References for DMH4
References are publications that support the biological activity of the product.
Fraley et al (2002) Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharmacokinetics. Bioorg.Med.Chem.Lett. 12 3537 PMID: 12443771
Hao et al (2010) In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors. ACS Chem.Biol. 5 245 PMID: 20020776
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Keywords: DMH4, DMH4 supplier, VEGFR-2, inhibitors, inhibits, dorsomorphin, vascular, endothelial, growth, factor, receptor-2, KDR, VEGFR, 4471, Tocris Bioscience
1 Citation for DMH4
Citations are publications that use Tocris products. Selected citations for DMH4 include:
Lee et al (2017) Carbohydrate-binding protein CLEC14A regulates VEGFR-2- and VEGFR-3-dependent signals during angiogenesis and lymphangiogenesis. J Clin Invest 127 457 PMID: 27991863
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Angiogenesis in Cancer Poster
This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.
Pathways for DMH4
