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Submit ReviewDMPQ dihydrochloride
Description: Potent, selective inhibitor of PDGFRβ
Chemical Name: 5,7-Dimethoxy-3-(4-pyridinyl)quinoline dihydrochloride
Purity: ≥99% (HPLC)
Biological Activity for DMPQ dihydrochloride
DMPQ dihydrochloride is a potent and selective inhibitor of human vascular β-type platelet derived growth factor receptor tyrosine kinase (PDGFRβ) (IC50 = 80 nM). Displays > 100-fold selectivity over EGFR tyrosine kinase, erbB2, p56, protein kinase A and protein kinase C.
Technical Data for DMPQ dihydrochloride
| M. Wt | 339.22 |
| Formula | C16H14N2O2.2HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1123491-15-5 |
| PubChem ID | 45073427 |
| InChI Key | YBBAOKYVJCNJIV-UHFFFAOYSA-N |
| Smiles | COC1=CC(OC)=C2C(N=CC(C3=CC=NC=C3)=C2)=C1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for DMPQ dihydrochloride
References for DMPQ dihydrochloride
References are publications that support the biological activity of the product.
Dolle et al (1994) 5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular β-type platelet-derived growth factor receptor tyrosine kinase J.Med.Chem. 37 2627 PMID: 8064792
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Keywords: DMPQ dihydrochloride, DMPQ dihydrochloride supplier, Potent, selective, inhibitors, inhibits, PDGFRβ, PDGFRbeta, PDGFRb, Platelet, Derived, Growth, Factors, Receptors, Receptor, Tyrosine, Kinases, RTKs, PDGFR, 1222, Tocris Bioscience
1 Citation for DMPQ dihydrochloride
Citations are publications that use Tocris products. Selected citations for DMPQ dihydrochloride include:
Srinivasan (2018) Substrate stiffness modulates the multipotency of human neural crest derived ectomesenchymalstem cells via CD44 mediated PDGFR signaling. Biomaterials 167 153 PMID: 29571051
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