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DSR 6434

Cat. No. 4809 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent TLR7 agonist
Chemical Name: 6-Amino-2-(butylamino)-9-[[6-[2-(dimethylamino)ethoxy]-3-pyridinyl]methyl]-7,9-dihydro-8H-purin-8-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for DSR 6434

DSR 6434 is a potent TLR7 agonist (EC50 = 7.2 nM). Activates several immune effector cells in vitro. Suppresses metastasis in vivo and enhances efficacy of radiation therapy in a model of colorectal carcinoma.

Compound Libraries for DSR 6434

DSR 6434 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for DSR 6434

M. Wt 400.48
Formula C19H28N8O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1059070-10-8
PubChem ID 25071151
InChI Key SSZHESNDOMBSRV-UHFFFAOYSA-N
Smiles O=C2N(CC3=CC=C(OCCN(C)C)N=C3)C1=NC(NCCCC)=NC(N)=C1N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DSR 6434

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 20.02 50
DMSO 40.05 100

Preparing Stock Solutions for DSR 6434

The following data is based on the product molecular weight 400.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.5 mL 12.49 mL 24.97 mL
5 mM 0.5 mL 2.5 mL 4.99 mL
10 mM 0.25 mL 1.25 mL 2.5 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets for DSR 6434

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for DSR 6434

References are publications that support the biological activity of the product.

Adlard et al (2014) A novel systemically administered Toll-like receptor 7 agonist potentiates the effect of ionizing radiation in murine solid tumor models. Int.J.Cancer 135 820 PMID: 24390981

Nakamura et al (2013) Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor 7 agonists with high water solubility. Bioorg.Med.Chem.Lett. 23 669 PMID: 23265901

If you know of a relevant reference for DSR 6434, please let us know.

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Citations for DSR 6434

Citations are publications that use Tocris products.

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Reviews for DSR 6434

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Pathways for DSR 6434

Toll-like Receptor Signaling Pathway

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.