Dynamin inhibitory peptide

Discontinued Product

1774 has been discontinued.

View all Dynamin products.
Description: Dynamin inhibitor
Alternative Names: P4
Purity: ≥95% (HPLC)
Datasheet
Citations (13)
Reviews

Biological Activity for Dynamin inhibitory peptide

Dynamin inhibitory peptide is a peptide inhibitor of the GTPase dynamin; competitively blocks binding of dynamin to amphiphysin thus prevents endocytosis when administered intracellularly. Reduces GABAA receptor internalization and increases miniature ISPC amplitude and frequency in neurons expressing GABAA receptors.

Cell-permeable version also available.

Technical Data for Dynamin inhibitory peptide

M. Wt 1121.26
Formula C47H80N18O14
Sequence QVPSRPNRAP
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 251634-21-6
PubChem ID 90488708
InChI Key LHQOQXYEPUSHJL-LNIRUYPRSA-N
Smiles [H]N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Dynamin inhibitory peptide

Certificate of Analysis / Product Datasheet
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References for Dynamin inhibitory peptide

References are publications that support the biological activity of the product.

Grabs et al (1997) The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence. J.Biol.Chem. 272 13419 PMID: 9148966

Kittler et al (2000) Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons. J.Neurosci. 20 7972 PMID: 11050117

Nong et al (2003) Glycine binding primes NMDA receptor internalization. Nature 422 302 PMID: 12646920

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Keywords: Dynamin inhibitory peptide, Dynamin inhibitory peptide supplier, Dynamin, inhibitors, inhibits, Mitosis, Epac, GTPases, P4, 1774, Tocris Bioscience

13 Citations for Dynamin inhibitory peptide

Citations are publications that use Tocris products. Selected citations for Dynamin inhibitory peptide include:

Xia et al (2007) Activity-dependent synaptic plasticity in retinal ganglion cells. J Neurosci 27 12221 PMID: 17989288

Chamma et al (2013) Activity-dependent regulation of the K/Cl transporter KCC2 membrane diffusion, clustering, and function in hippocampal neurons. J Neurosci 33 15488 PMID: 24068817

Dewerchin et al (2008) Surface-expressed viral proteins in feline infectious peritonitis virus-infected monocytes are internalized through a clathrin- and caveolae-independent pathway. J Gen Virol 89 2731 PMID: 18931069

Grueter et al (2008) In vivo metabotropic glutamate receptor 5 (mGluR5) antagonism prevents cocaine-induced disruption of postsynaptically maintained mGluR5-dependent long-term depression. J Neurosci 28 9261 PMID: 18784306


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