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Submit Review(E)-FeCP-oxindole
Description: Selective VEGFR-2 inhibitor
Chemical Name: (E)-3-Ferrocenylmethylidene-1,3-dihydro-2H-indol-2-one
Biological Activity for (E)-FeCP-oxindole
Selective inhibitor of human vascular endothelial cell growth factor receptor 2 (VEGFR-2) (IC50 = 214 nM). Displays anticancer activity (IC50< 1 μM against B16 murine melanoma lines). Does not significantly inhibit VEGFR1 or PDGFRa or b at a concentration of 10μM.
Geometric Isomer also available.
Technical Data for (E)-FeCP-oxindole
| M. Wt | 329.17 |
| Formula | C19H15FeNO |
| Storage | Store at +4°C |
| CAS Number | 884338-18-5 |
| PubChem ID | 124080971 |
| InChI Key | JGKCUURLEMXRGX-ANOGCNOSSA-N |
| Smiles | [Fe++].[CH-]1C=CC=C1.O=C1NC2=CC=CC=C2\C1=C/C1=C[CH-]C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for (E)-FeCP-oxindole
References for (E)-FeCP-oxindole
References are publications that support the biological activity of the product.
Spencer et al (2011) Synthesis and evaluation of metallocene containing methylene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors. Metallomics 3 600 PMID: 21359402
Spencer et al (2009) Structural and biological investigation of ferrocene-substituted 3-methylidene-1,3-dihydro-2H-indol-2-ones. Dalton Transact. 6 918
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Keywords: (E)-FeCP-oxindole, (E)-FeCP-oxindole supplier, selective, human, VEGFR-2, inhibitors, inhibits, vascular, endothelial, cell, growth, factors, receptors, RTKs, receptor, tyrosine, kinases, VEGFR, 3882, Tocris Bioscience
Citations for (E)-FeCP-oxindole
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Currently there are no citations for (E)-FeCP-oxindole.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Angiogenesis in Cancer Poster
This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.
Pathways for (E)-FeCP-oxindole
