Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewEc2la
Description: Positive allosteric modulator of CB2 receptors; active in vivo
Chemical Name: N-[5-Bromo-1-[(4-fluorophenyl)methyl]-1,2-dihydro-4-methyl-2-oxo-3-pyridinyl]cycloheptanecarboxamide
Purity: ≥98% (HPLC)
Biological Activity for Ec2la
Ec2la is a CB2 receptor positive allosteric modulator. Enhances CP 55940 (Cat. No. 0949) and 2-Arachidonylglycerol (Cat. No. 1298)-stimulated binding of [35S]GTPγS to CB2 receptors, but has no effect in the absence of agonist. Exhibits antinociceptive effects in an animal model of neuropathic pain.
Compound Libraries for Ec2la
Ec2la is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for Ec2la
| M. Wt | 435.33 |
| Formula | C21H24BrFN2O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2244579-87-9 |
| PubChem ID | 137553165 |
| InChI Key | NSGDYZCDUPSTQT-UHFFFAOYSA-N |
| Smiles | CC1=C(C(N(C=C1Br)CC2=CC=C(C=C2)F)=O)NC(C3CCCCCC3)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Ec2la
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 8.71 | 20 |
Preparing Stock Solutions for Ec2la
The following data is based on the product molecular weight 435.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 11.49 mL | 57.43 mL | 114.86 mL |
| 1 mM | 2.3 mL | 11.49 mL | 22.97 mL |
| 2 mM | 1.15 mL | 5.74 mL | 11.49 mL |
| 10 mM | 0.23 mL | 1.15 mL | 2.3 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for Ec2la
References for Ec2la
References are publications that support the biological activity of the product.
Gado et al (2019) Identification of the first synthetic allosteric modulator of the CB2 receptors and evidence of its efficacy for neuropathic pain relief. J.Med.Chem. 62 276 PMID: 29990428
If you know of a relevant reference for Ec2la, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Ec2la, Ec2la supplier, CB2, positive, allosteric, modulator, PAM, cannabinoid, neuropathic, pain, Ec21a, Ec2Ia, Receptors, 6832, Tocris Bioscience
Citations for Ec2la
Citations are publications that use Tocris products.
Currently there are no citations for Ec2la. Do you know of a great paper that uses Ec2la from Tocris? Please let us know.
Reviews for Ec2la
There are currently no reviews for this product. Be the first to review Ec2la and earn rewards!
Have you used Ec2la?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.