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EG 00229 trifluoroacetate

Cat. No. 6986 3 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to NRP1
Chemical Name: N2-[[3-[(2,1,3-Benzothiadiazol-4-ylsulfonyl)amino]-2-thienyl]carbonyl]-L-arginine trifluoroacetate
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews
Literature (1)
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for EG 00229 trifluoroacetate

EG 00229 trifluoroacetate is a neuropilin 1 (NRP1) antagonist; inhibits VEGFA binding to the NRP1 b1 CendR binding pocket. Has no effect on VEGFA binding to VEGFR-1 and VEGFR-2. Reduces VEGFA-induced VEGFR-2 tyrosine phosphorylation in HUVECs. Also attenuates VEGFA-induced HUVEC cell migration and reduces A549 lung carcinoma cell viability in vitro. Inhibits binding of CendR motif in S1 protein of SARS-CoV-2 to NRP1, and reduces efficiency of SARS-CoV-2 infection in Caco-2 cells.

Compound Libraries for EG 00229 trifluoroacetate

EG 00229 trifluoroacetate is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for EG 00229 trifluoroacetate

M. Wt 611.59
Formula C17H19N7O5S3.CF3CO2H
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1210945-69-9
PubChem ID 45142253
InChI Key ZYQBITUOSRZDTG-MERQFXBCSA-N
Smiles O=S(C1=CC=CC2=NSN=C12)(NC3=C(C(N[C@H](C(O)=O)CCCNC(N)=N)=O)SC=C3)=O.FC(F)(F)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for EG 00229 trifluoroacetate

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 61.16 100
2eq. NaOH 61.16 100

Preparing Stock Solutions for EG 00229 trifluoroacetate

The following data is based on the product molecular weight 611.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.64 mL 8.18 mL 16.35 mL
5 mM 0.33 mL 1.64 mL 3.27 mL
10 mM 0.16 mL 0.82 mL 1.64 mL
50 mM 0.03 mL 0.16 mL 0.33 mL

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Product Datasheets for EG 00229 trifluoroacetate

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for EG 00229 trifluoroacetate

References are publications that support the biological activity of the product.

Jarvis et al (2010) Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction. J.Med.Chem. 53 2215 PMID: 20151671

Daly et al (2020) Neuropilin-1 is a host factor for SARS-CoV-2 infection. Science 370 861 PMID: 33082294

If you know of a relevant reference for EG 00229 trifluoroacetate, please let us know.

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3 Citations for EG 00229 trifluoroacetate

Citations are publications that use Tocris products. Selected citations for EG 00229 trifluoroacetate include:

Daly et al (2020) Neuropilin-1 is a host factor for SARS-CoV-2 infection. Science 370 861 PMID: 33082294

Curtis A et al (2021) Novel Compounds Targeting Neuropilin Receptor 1 with Potential To Interfere with SARS-CoV-2 Virus Entry. ACS Chem Neurosci 12 1299-1312 PMID: 33787218

Rajesh et al (2021) SARS-CoV-2 spike protein co-opts VEGF-A/neuropilin-1 receptor signaling to induce analgesia. Pain 162 243-252 PMID: 33009246

Do you know of a great paper that uses EG 00229 trifluoroacetate from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Pathways for EG 00229 trifluoroacetate

VEGF Signaling Pathway

VEGF Signaling Pathway

VEGF signaling pathway is involved in embryonic vascular development (vasculogenesis) and in the formation of new blood vessel (angiogenesis). It also induces cell migration, proliferation and survival.