Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewEMI 48
Description: Inhibitor of EGFR mutants
Chemical Name: 7-(Diethylamino)-3-(5-methyl-2-benzoxazolyl)-2H-1-benzopyran-2-one
Purity: ≥98% (HPLC)
Biological Activity for EMI 48
EMI 48 is an inhibitor of mutant EGFR; it inhibits L858R/T970M/C797S mutants and ex19del/T790M/C797S triple mutants (inhibitory effects at 5 μM) but has no effect on wild-type EGFR. EMI 48 induces EGFR degradation (<5 μM), and inhibits activation of ERK, S6 and AKT.
Technical Data for EMI 48
| M. Wt | 348.4 |
| Formula | C21H20N2O3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 34564-13-1 |
| PubChem ID | 15538560 |
| InChI Key | PTAGJQADNFQMGR-UHFFFAOYSA-N |
| Smiles | CCN(C1=CC=C2C=C(C(OC2=C1)=O)C3=NC4=C(C=CC(C)=C4)O3)CC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for EMI 48
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 6.97 | 20 with gentle warming |
Preparing Stock Solutions for EMI 48
The following data is based on the product molecular weight 348.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 14.35 mL | 71.76 mL | 143.51 mL |
| 1 mM | 2.87 mL | 14.35 mL | 28.7 mL |
| 2 mM | 1.44 mL | 7.18 mL | 14.35 mL |
| 10 mM | 0.29 mL | 1.44 mL | 2.87 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for EMI 48
References for EMI 48
References are publications that support the biological activity of the product.
Saraon et al (2020) A drug discovery platform to identify compounds that inhibit EGFR triple mutants. Nat.Chem.Biol. 16 577 PMID: 32094923
If you know of a relevant reference for EMI 48, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: EMI 48, EMI 48 supplier, EMI48, EGFR, inhibitors, inhibits, degradation, mutant, endothelial, growth, factors, receptors, L858R, T970M, C797S, ex19del, 7424, Tocris Bioscience
Citations for EMI 48
Citations are publications that use Tocris products.
Currently there are no citations for EMI 48. Do you know of a great paper that uses EMI 48 from Tocris? Please let us know.
Reviews for EMI 48
There are currently no reviews for this product. Be the first to review EMI 48 and earn rewards!
Have you used EMI 48?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Angiogenesis in Cancer Poster
This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.