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Submit ReviewEMI 48
Description: Inhibitor of EGFR mutants
Chemical Name: 7-(Diethylamino)-3-(5-methyl-2-benzoxazolyl)-2H-1-benzopyran-2-one
Purity: ≥98% (HPLC)
Biological Activity for EMI 48
EMI 48 is an inhibitor of mutant EGFR; it inhibits L858R/T970M/C797S mutants and ex19del/T790M/C797S triple mutants (inhibitory effects at 5 μM) but has no effect on wild-type EGFR. EMI 48 induces EGFR degradation (<5 μM), and inhibits activation of ERK, S6 and AKT.
Technical Data for EMI 48
| M. Wt | 348.4 |
| Formula | C21H20N2O3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 34564-13-1 |
| PubChem ID | 15538560 |
| InChI Key | PTAGJQADNFQMGR-UHFFFAOYSA-N |
| Smiles | CCN(C1=CC=C2C=C(C(OC2=C1)=O)C3=NC4=C(C=CC(C)=C4)O3)CC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for EMI 48
References for EMI 48
References are publications that support the biological activity of the product.
Saraon et al (2020) A drug discovery platform to identify compounds that inhibit EGFR triple mutants. Nat.Chem.Biol. 16 577 PMID: 32094923
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Keywords: EMI 48, EMI 48 supplier, EMI48, EGFR, inhibitors, inhibits, degradation, mutant, endothelial, growth, factors, receptors, L858R, T970M, C797S, ex19del, 7424, Tocris Bioscience
Citations for EMI 48
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