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Submit ReviewEML 425
Description: Reversible and non-competitive CBP/p300 inhibitor
Chemical Name: 5-[(4-Hydroxy-2,6-dimethylphenyl)methylene]-1,3-bis(phenylmethyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
Purity: ≥98% (HPLC)
Biological Activity for EML 425
EML 425 is a reversible and non-competitive CBP/p300 inhibitor (IC50 values are 1.1 and 2.9 μM, respectively). Cell permeable.
Compound Libraries for EML 425
EML 425 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for EML 425
| M. Wt | 440.49 |
| Formula | C27H24N2O4 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1675821-32-5 |
| PubChem ID | 91826273 |
| InChI Key | LUGQBJDYUPNAQQ-UHFFFAOYSA-N |
| Smiles | CC1=C(/C=C2C(N(CC3=CC=CC=C3)C(N(CC4=CC=CC=C4)C\2=O)=O)=O)C(C)=CC(O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for EML 425
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.05 | 100 |
Preparing Stock Solutions for EML 425
The following data is based on the product molecular weight 440.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.27 mL | 11.35 mL | 22.7 mL |
| 5 mM | 0.45 mL | 2.27 mL | 4.54 mL |
| 10 mM | 0.23 mL | 1.14 mL | 2.27 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.45 mL |
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Product Datasheets for EML 425
References for EML 425
References are publications that support the biological activity of the product.
Milite et al (2015) A novel cell-permeable, selective, and noncompetitive inhibitor of KAT3 histone acetyltransferases from a combined molecular pruning/classical isosterism approach. J.Med.Chem. 58 2779 PMID: 25730130
If you know of a relevant reference for EML 425, please let us know.
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Keywords: EML 425, EML 425 supplier, EML425, CBP, CREB, proteins, histone, lysine, acetyltransferases, inhibits, inhibitors, HAT, KAT, reversible, non-competitive, Histone, Acetyltransferases, Post-translational, Modifications, 5646, Tocris Bioscience
Citations for EML 425
Citations are publications that use Tocris products.
Currently there are no citations for EML 425. Do you know of a great paper that uses EML 425 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.